first_img Read Full Story A drug already approved for treating other diseases may be useful as a treatment for cerebral malaria, according to researchers at Harvard T. H. Chan School of Public Health. They discovered a novel link between food intake during the early stages of infection and the outcome of the disease, identifying two molecular pathways that could serve as new targets for treatment.“We have known for a long time that nutrition can affect the course of infectious disease, but we were surprised at how rapidly a mild reduction in food intake could improve outcome in a mouse malaria model,” said senior author James Mitchell, associate professor of genetics and complex diseases. “However, the real importance of this work is the identification of unexpected molecular pathways underlying cerebral malaria that we can now target with existing drugs.”The study appears online January 30, 2015 in Nature Communications.Cerebral malaria — a severe form of the disease — is the most serious consequence of infection by the parasite Plasmodium falciparum, resulting in seizures, coma, and death. Currently there is a lack of safe treatment options for cerebral malaria, particularly for use in children, who represent the majority of cases.last_img read more

first_imgHarvard’s Houghton Library recently acquired the 3,000th item in its “MS Am” collection of American manuscripts, literary papers, historical documents, and artifacts.The first such acquisition, in 1874, was a gift: the 1829-74 correspondence of Charles Sumner — 170 albums in all, said Leslie Morris, Houghton’s curator of modern books and manuscripts. Sumner was a longtime Massachusetts senator and abolitionist who once taught at Harvard Law School, but he is best remembered as the fire-and-facts orator who led the anti-slavery wing of the Republican Party leading up to and during the Civil War.Given Sumner’s passion for racial justice, it is fitting that MS Am 3000 is a work by a 20th-century writer who spent his life struggling with the culturally embedded forms of racism that survived well beyond the Civil War.Novelist, playwright, and essayist James Baldwin (1924-87) was a black man who grew up in the racially divided and rancorous America that Sumner once dreamed would soon be history. (In 1870, he introduced what became the Civil Rights Act of 1875, whose language of racial freedom and inclusion sounds modern. In 1883, the Supreme Court declared it unconstitutional, lighting the fuse for the Jim Crow era.)MS Am 3000 is more than the joining of two famous Americans, however. The document, an undated typescript of an unfinished Baldwin play called “The Welcome Table,” includes a central character based on a Harvard professor.“Peter Davis was me,” said Henry Louis Gates Jr. in a conversation about the journalist who is one of the play’s main characters. Gates — who at age 22 met Baldwin in France — is Harvard’s Alphonse Fletcher University Professor and the director of the Hutchins Center for African and African American Research.Another character in the play — Gates averred, and other scholars agree — is based on Josephine Baker (1906-75), the iconic American dancer who took Paris by storm in the 1920s and ’30s. In her day Baker was as famous as the Beatles, in part for her sensual dance routines and minimal costumes. Starting in the 1950s, she gave her voice to the Civil Rights movement and to the idea of racial inclusion. She dubbed her family of 12 adopted children, racially diverse, “the Rainbow Tribe.”What brought Baldwin, Gates, and Baker together was an August 1973 visit to the author’s villa in St. Paul-de-Vence in Provence. Gates was a London-based journalist at the time, assigned to a story on black American expatriates. He rented a car and drove Baker from her home in Monte Carlo to Baldwin’s villa. It was a reunion of the aging entertainer and the American author. The meeting was to be their last. Baker died two years later.In an essay about the meeting, Gates was wry about himself — “with my gold-rimmed, cool-blue shades and my bodacious Afro,” he wrote — and awed both by the company and by the heavenly setting of southeastern France in the foothills of the Alps near the Mediterranean. “The air carries the smells of wild thyme, pine, and centuries-old olive trees,” he wrote.The setting of the meal itself was a welcome table, which Gates called “a metaphor from the black sacred tradition. It’s where the good go when they die and go to heaven.”That welcome table was also the spark that gave the play the shape it has in the Houghton typescript and in the other surviving drafts. “There was only one night Josephine Baker was brought to James Baldwin’s house,” said Gates. “He wrote it because of that night.”In his essay, “The Welcome Table: James Baldwin in Exile,” Gates wrote that his personal day of awe in France had its origins at a church summer camp in West Virginia when he was 14. An Episcopal priest from New England had loaned him a copy of “Notes of a Native Son” (1955), Baldwin’s first work of nonfiction. “It was the first time I had heard a voice capture the terrible exhilaration and anxiety of being a person of African descent in this country,” Gates wrote. “The book performed the Adamic function of naming the complex racial dynamic of the American cultural imagination.”Gates’ visit to Baldwin was central to the play. But the full origins are more complex. For one, Baldwin had started a version of the play in 1967 when he was living in Istanbul. Its thematic threads survive as a meditation on sex and gender, but “The Welcome Table” of the early conception had a rougher edge. It was to be a “drawing-room nightmare,” Baldwin wrote, and titled “121 Days of Sodom.” The work evolved after the 1973 gathering, and a black journalist became the catalyst for reuniting old friends.The four known typescripts tell a complicated story of an author changing his mind. Gates has a typescript copy of his own, in storage. He appears there as a young Peter Davis, he said. But in the Houghton copy Davis is a middle-aged man — old enough to have served in World War II; to have a grown son; and to act as a mentor to Daniel, another writer at the play’s welcome table.“However old he made me — that’s his business,” said Gates of Baldwin, whom he continued to meet as a friend. The Houghton typescript, he added, “is clearly a revision.” But Baldwin’s own obsessions as an artist and essayist remain in full flower in the Houghton typescript: the black experience, sliding and eliding sexual identities, racial mixing, class divisions, the solace of drink, the hubris of American political power, and the double edge of exile.In all, “The Welcome Table” mingles Baldwin the fiction writer with Baldwin the essayist. Here, the author’s notoriously (and attractively) complex sentences are bent to the clarity and directness of dialogue.On the last page of the typescript, two characters stand to one side. One says, with the spacing Baldwin typed out, “Shall — we — drink to the welcome table?” The answer seems to be, from a writer who was near death as he revised the play: “Yes.”Of the known typescripts of “Welcome,” two have Harvard ties: the one Gates owns and the one at Houghton: 72 pages, with revisions, and a few unrelated pieces, including a poem. The others are at the New York Public Library’s Schomburg Center for Research in Black Culture, and in the hands of Walter Dallas, a Washington, D.C., freelance theater director.Taken together, the drafts present a tangle of directions and intentions. TheHoughton copy contains numbering changes, inserted pages, and two different types of paper, suggesting different intervals of revision. To unravel all this will take the eyes of a Baldwin scholar. It is, said Morris, “an obvious project for someone to take on.”last_img read more

first_imgNotre Dame appointed Gregory P. Crawford, physics professor and dean of the College of Science, to associate provost and vice president, effective July 1, 2015, according to a University press release.“Greg’s passion, creativity, intellect, energy and enthusiasm have taken the College of Science to new heights,” Provost Thomas G. Burish said in a statement. “These same attributes will serve the University well as he establishes a physical presence for Notre Dame in the West. We are grateful for his six years of service as dean and look forward to his contributions in his new role.”Crawford will expand and develop Notre Dame’s connections in the San Francisco Bay Area of California before extending his work to include the whole state, the press release stated. His work will include recruiting top students, finding new internship and employment opportunities for current undergraduates and exploring connections that could help provide and fund sabbaticals for faculty.“Extending our virtues and values to northern California is only the next step in Notre Dame’s goal of expanding across the state and elevating our impact on the world as a force for good – building on our long tradition of service to humanity and our accelerating achievements in that cause,” Crawford said in a statement. “I am profoundly grateful and inspired by the students, faculty and staff of the College of Science, who devote themselves, day in and day out, to fulfilling Notre Dame’s mission.”Crawford began his role as dean in 2008 and since then has overseen more than 500 faculty, staff and postdoctoral researchers, the press release stated. Before that, he served at Brown University as dean of engineering from 2006 to 2008 as well as professor of physics and engineering from 1996 to 2008.Tags: associate provost, Gregory P. Crawford, Vice Presidentlast_img read more

first_imgHeritage Week at Saint Mary’s added a new asset to its week of events: an alumnae and student mixer. After the plans for the annual poetry reading event at Riedinger House fell through, the mission committee created the new event for students to meet with alumnae and talk with them one-on-one in the historical house.Junior biology major Lydia Lorenc planned the new event with the goal to get alumnae involved in Heritage Week.“It’s exciting to see how excited alumnae are to see us,” Lorenc said. “You learn another perspective.”Shay Jolly, a 2005 graduate and assistant director of alumnae relations, said the event was a good opportunity to engage in Heritage Week.“[Alumnae are] a good part of our heritage,” Jolly said, “If it wasn’t for them we couldn’t go forward.”Some alumnae wanted to reach out to current students and see what the campus is like today. Maureen Parsons, a 2013 alumna, came to the event because she wanted to meet the current students.“I always enjoy coming back to campus and engaging with students,” Parsons said.Mary Ellen Koepfle, a 1978 marketing and finance graduate, wanted to interact with students during the mixer.“I want to know how to keep Saint Mary’s vibrant,” Koepfle said.Jude Anne Hastings, a 1996 alumna, took the opportunity to see what was happening on campus.“We like to see students and support Saint Mary’s in any way we can,” Hastings said.Students who attended were also curious to meet alumna and get advice from them. Freshman Emma Fruend thought the mixer showed Saint Mary’s was a good community.“Everyone seems friendly and nice and wants to share,” Freund said.Junior biology major Kaitlyn Cartone said she enjoyed getting to talk to alumnae individually at the house.“I think just seeing where everyone is after graduation is cool,” Cartone said.The event was also a way students could explore the closed Reidinger House. Freshman Abby Seubert was originally curious in the mixer because she wanted to see the house.“It was always cool walking around and seeing what is behind the door [of Reidinger],” Seubert said.Koepfle said she advises students to enjoy their time and to find a favorite spot on campus.“Enjoy every single minute at Saint Mary’s, it goes by so fast,” Koepfle said. “Find your favorite place on campus.”Hastings said to take advantage of the Saint Mary’s community.“Soak up every opportunity Saint Mary’s gives you, it’s hard to get it out in the real world,” Hastings said.The mixer at heritage week also made students and alumna proud of their school. Rachel Tomas Morgan, a 1991 graduate, said the school made her the strong woman she is today.“I’m proud to be a Saint Mary’s grad,” Tomas Morgan said. “[The school] helped me to be a strong woman.”Cartone said the event from the week gave perspective to what the college was like.“[You] see where you came from,” Cartone said.Tags: Alumnae, Heritage Week, saint mary’slast_img read more

first_imgShare:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to email this to a friend (Opens in new window) Stock Image.JAMESTOWN – Law enforcement are ramping up efforts to crack down on impaired and distracted driving over the Halloween weekend.The New York State Police, working with local law enforcement agencies, launched a special campaign featuring sobriety checkpoints and additional DWI patrols. Troopers will be using both marked State Police vehicles and unmarked vehicles as part of this crackdown.Law enforcement will also be looking for motorists who are using their phones and other electronic devices while behind the wheel.  Drivers are also reminded to “move over” for stopped emergency and hazard vehicles stopped on the side of the road.Police say Halloween night can be especially dangerous due to the high number of children and families out trick-or-treating. The National Highway Traffic Safety Administration reports that from 2014 to 2018, 145 people were killed nationwide in impaired driving fatalities on Halloween night. According to the group, 41% of the motor vehicle fatalities on Halloween night involved impaired drivers.The New York State Police recommend these simple tips to prevent impaired driving:Plan a safe way home before the fun begins;Before drinking, designate a sober driver;If you’re impaired, use a taxi or ride sharing service, call a sober friend or family member, or use public transportation;Use your community’s sober ride program;If you suspect a driver is drunk or impaired on the road, don’t hesitate to contact local law enforcement;If you know someone who is about to drive or ride while impaired, take their keys and help them make other arrangements to get to where they are going safely.During last year’s initiative, State Troopers arrested 280 people for impaired driving and issued 21,467 total tickets. Troopers also investigated 2,092 crashes, which resulted in three fatalities and 269 people injured.State Police will also be targeting the illegal sale of alcohol to minors through underage drinker enforcement details statewide.last_img read more

first_imgDear Mountain Mama,One “thud” and I fell out of love with whitewater kayaking.When I flipped and hit my head on a rock, the primal urge to be right-side-up consumed me.  All my friends who kayak have progressed and now paddle harder rivers than me.I want to start kayaking again, but from the seat of a kayak the top of every rapid looks chock-full of rocks. Everywhere I see the potential for getting hurt. How do I conquer my fear of rocks?Thanks,Got the Kayaking ItchDear Kayaking Itch:Hitting your head on a rock is terrifying. The sound of the impact echoes as you remain underwater, unable to breathe and unsure whether to risk rolling onto a rock or waiting.Most hard-boaters have at least one I-hit-my-head-so-hard-I-considered-quitting-kayaking-forever story. Those who don’t are either liars or have hit their head too many times to remember.The saying “look where you want to go” applies aptly to whitewater.When looking downstream, if you focus on every rock, eddy line, or hole, the river will appear dangerous and difficult. Instead of focusing on all the spots to avoid, keep your gaze fixed on all of the water moving downstream. Some people call these “V”s as the water often resembles the letter when looking downstream. When you look at all the water instead of the hazards, most rivers are full of possible good, clean lines. Keep your eyes glued on where you want to go.As your paddling progresses, take another look at rocks. Some rocks guard exquisite eddies that provide a break in the middle of a chaotic rapid. But in order to access those sweet eddies, you must be willing to confront your fear of rocks. Paddling close to rocks might be the best line on some creeks, so it helps to start exploring on mild stretches of water where you feel comfortable.Many say kayaking is a metaphor for life. In life, we often attempt to avoid the hazards — the difficult conversation, the long overdue financial decision, or the number of fast food stops. We ignore the difficult to cultivate joyful and fun-filled lives. Sometimes what we ignore festers, spilling over into bad days. When we’re willing to cozy up to difficulties instead of shirking away from them, we learn — both on and off the water.In the beginning, paddle clean lines. But once you’ve got some dry-hair runs under your sprayskirt, befriend a rock or two.Paddle On!OLYMPUS DIGITAL CAMERAlast_img read more

first_imgQUICK HITSTrain interrupts marathon • D.C. Bike Share expands • Newborns in NikesFLASHPOINTUnsolved Mysteries: Four Crimes and Disappearances from Parks and Forests in Appalachia.THE DIRTWater in Appalachia—the next Flint?TRAIL MIXQ&A with My Morning Jacket’s Jim James.TOP ADVENTURE TOWNSReaders selected their favorite outdoor hubs. Find out which towns are tops in the mountains. Plus: how are many mountain towns transitioning from coal economies to recreation destinations?The WinnersExplore More Top TownsSpotlight: Knoxville’s Urban WildernessMountain of Money: The Death of CoalA Brighter FuturePEAK GEAR AWARDS 2016Our athletes, editors, and experts select their favorite gear for every sport. Want to buy from Blue Ridge-based companies? We’ve also highlighted locally loved outdoor products.EXERCISE ADDICTTravis Muehleisen used to be strung out on opiates. Now he’s hooked on running.CAVING CONUNDRUMShould caves be closed to climbers in order to protect bats? Scientists and spelunkers are coming together to save an endangered species.CONFESSIONS OF A RIVER GUIDE“For 41% of my life now, I have been guiding people down the magical ribbons of rivers.”THE GREEN RACE GAME PLANWhat to look for in this year’s Green Race.WHY DO WE DO THIS TO OURSELVESTwo hikers attempt a thru-hike of the 200-mile Cumberland Trail.THE THINGS THEY CARRIED (AND WISHED THEY HADN’T)A Field Survey of Thru-Hikers Backpacks.last_img read more

first_imgSouth Carolina’s attorney general joins offshore drilling lawsuit against Trump administrationS.C. Attorney General Alan Wilson joined a lawsuit on Monday against the Trump administration to block seismic testing for oil and gas off of the S.C. coast. Supported by Republican Governor Henry McMaster, Wilson became the first Republican attorney general to join the lawsuit, which already includes 16 S.C. cities, nine environmental groups, and nine Democratic state attorney generals. The lawsuit hopes to stop exploration for oil and gas off of the Atlantic coast, which could harm the environment and impact S.C. tourism. S.C.’s coastal communities fear that drilling could result in oil spills, which would drive away vacationers. Seismic testing is also concerning because of its harm to marine life, which the lawsuit says could kill thousands of dolphins, whales and fish. The last species of a Hawaiian land snail diesGeorge, the last known Achatinella apexfulva, a Hawaiian land snail, died on January 1 at approximately 14 years of age. He was born as a final attempt to save his species. Back in 1997, the last 10 known Achatinella apexfulva were brought into the lab at University of Hawaii to try to increase their numbers. George was the only offspring that survived. He lived alone in a cage at Hawaii’s Department of Land and Natural Resources snail lab in Kailua, Oahu. His death takes place amid a crisis for native snails on the islands of Hawaii. Hawaii’s snail population has been destroyed by a number of invasive species, including rats and Jackson’s chameleons. The native snail’s biggest threat is the rosy wolfsnail, a predatory snail from Florida introduced to the islands back in the1950’s to control agricultural pests. Joshua Tree National Park to close after visitor damage during government shutdownBeginning today, Joshua Tree National Park will close temporarily because of damaged caused by visitors during the partial government shutdown. There are few rangers at the park to prevent off-roading and since the shutdown some visitors have created new roads that have destroyed the park’s namesake tree. Since the shutdown, volunteers have stepped up to clean the 800,000-acre park. Law enforcement rangers will enforce the closure and continue to patrol the park until staff can complete the necessary cleanup and protection measures. This isn’t the first national park to close since the government shutdown. Parts of Yosemite National Park and much of Sequoia and Kings Canyon national parks are closed as well.last_img read more

first_imgHave you ever wished you could move money between institutions faster than two days? Guess what – YOUR WISH WILL BE GRANTED! NACHA  (The electronic payments association) has adopted a new rule to allow same-day ACH. Currently, most ACH settlement takes at least a day, if not two.If your institution is an ODFI, you will be able to submit same-day files a couple of times a day. About 99% of current ACH transactions will be eligible for same-day.  Deadlines will be 10:30 a.m. (EST) with settlement at 1:00 p.m. (EST), and 3:00 p.m. (EST) with settlement at 5:00 p.m. (EST). For same-day, they have proposed a 5.2-cent transaction.So that’s the gist of it, but what does that mean to the industry?Well, a few things…1. We will really need look at fraud. Most ACH fraud systems depend on the lag in transmission to look at the ACH file and determine what might be fraud. Also, many CUs use the lag to contact a member and determine if the transaction is real. With a compressed window, there is no doubt in my mind there is a group of fraudsters right now somewhere rubbing their hands together (in a slightly evil way), planning ways to work with these windows. Your operations will no doubt have to change and there will be a reaction to this via technology.For instance, does your fraud analytics partner have plans to add additional logic for same-day ACH transactions? That’s something I would look at closely. Not to mention the window for the fraudster grabbing the money from the remote FI is now shortened. Trust me, the fraudsters are watching this closely.2. Home Banking ACH payee validation: Today, most online ACH systems utilize a pre-credit/debit methodology to validate that a member truly owns the account at the remote institution. This methodology involves sending a small transaction to the remote account and having the member report back the transaction to unlock the account. Currently, this takes two days.So I ask… should it be done with the same-day transaction? It would definitely make the members happier. But would it also increase fraud? Something to ponder. Also, home banking platforms will have to be revised to support the cut off times. This revision will be a challenge, as members won’t be used to having a window for a payment.3. Should you charge for same-day? Or at least only give it away to your premium members? Only charge for credits? This is an age-old question now complicated by the introduction of same-day and the charge for it.4. How will this affect your payments strategy? Will bill pay slowly become obsolete as new faster payment channels emerge?There is plenty to think about here and a short time in which to do it. Phase 1 is credits, but you can bet the bigger players are revving up their engines for this. And if they do, your members will want to see it at your shop. So talk to your online ACH providers and find out their plan soon! 35SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr,John Best Financial technology service expert John Best crushes the reiterated maxim “thinking outside the box” to tiny particles, leveraging his lofty, yet proven, financial technology “innovativeness” for credit unions nationwide. Recently … Web: big-fintech.com Detailslast_img read more

first_imgThis is placeholder text continue reading » This post is currently collecting data… In April we provided initial takeaways for the impact of COVID-19 on overdraft services. We have learned a great deal as our team continues to work closely with clients on effective strategies to enhance recovery efforts. As promised, we have new insights to share based on monitoring and evaluating results for our financial institution clients over the past six months. Additionally, for a comprehensive view we analyzed data for all financial institutions across the nation.Listen as JMFA CEO John Cohron provides an overview of how community banks and credit unions are performing to recover earnings, client data trends, and performance highlights. You’ll also gain valuable perspective for addressing your overdraft program to enhance your results.EPISODE HIGHLIGHTS:1:24 – Performance highlights for JMFA clients—NSF/Overdraft income, transaction volumes, program utilization, waived and refunded fees, charge offs3:33 – Industry data comparisons for income decline4:58 – Factors for improved recovery results for JMFA clients5:35 – Reg E opt-ins and communication6:34 – Minimizing the impact of forecasted financial shortfalls7:28 – Compliance considerations and best practices8:48 – Areas of focus that will impact overall recovery resultscenter_img ShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblrlast_img read more