first_imgThe Peach Music Festival has detailed a number of additions to the lineup for their 2019 event set to take place from July 25th through 28th at Montage Mountain in Scranton, PA.Leading the list of artist additions are Warren Haynes and Grace Potter, who will mount a very special collaborative set at The Peach. The decorated pair of singer/guitarists will play together, solo, and backing each other as they perform songs from each of their respective repertoires and beyond. Cory Wong, the enigmatic guitarist often seen onstage with Vulfpeck, will also bring his solo band to Montage Mountain to join in the fun. Fan-favorite Colorado jam quartet Magic Beans has also been added to the Peach lineup, in addition to jam scene stalwarts Percy Hill and talented blues-rock guitarist Joanne Shaw Taylor.The Peach has also announced a new tradition, the Peach Guitar Pull. The festival will reimagine the traditional southern front porch guitar pull by gathering the best shredders in the rock, blues, and jam worlds and putting them together for the ultimate guitar aficionado’s experience. The Guitar Pull will be led by Scott Sharrard, former musical director for the late Gregg Allman, with guitar talents like Steve Kimock, Samantha Fish, and more set to participate. Additional Peach Guitar Pull participants will be announced as the event draws closer.Related: The Peach Festival, Live For Live Music Announce 2019 Media PartnershipThe newly added artists join and already-stellar lineup featuring two sets of Phil Lesh & Friends featuring Haynes and John Molo, two sets from Trey Anastasio Band, three by The String Cheese Incident, and a myriad of other exciting acts including Joe Russo’s Almost Dead, moe., Greensky Bluegrass, Lotus, Blues Traveler, Lettuce, Stephen Marley, Pigeons Playing Ping Pong (2 sets), The Marcus King Band, The Infamous Stringdusters, Yonder Mountain Sring Band, Billy Strings, Allman Betts Band, Jaimoe’s Jasssz Band, Aqueous, Ghost Light, Fruition, BIG Something, Larkin Poe, Magic City Hippies, Andy Frasco & The U.N., Southern Avenue, Organ Freeman, Kitchen Dwellers, Mungion, Hayley Jane & The Primates, and many more.See below for a full updated lineup. For more information, or to grab your passes to The Peach Music Festival 2019 now, head here.last_img read more

first_imgThe Naval Reserve Officers Training Corps (NROTC) prepares college students to serve as Naval officers after graduation. Eighty-four Notre Dame and Saint Mary’s undergraduates participate in this program. Known as “midshipmen,” students in the program this summer spent approximately a month completing various training courses, including spending time aboard active vessels and aircraft to prepare them to ultimately commission as officers. Rising sophomores, known as third-class midshipmen, participated in the Naval Reserve’s Career Orientation and Training for Midshipmen (CORTRAMID) program, which served as an introduction to the different communities within or associated with the Navy, including aviation, surface service, subsurface service and the Marine Corps. Second-class and first-class midshipmen — rising juniors and seniors, respectively — completed “summer cruises,” which entailed experiencing naval service first-hand on a ship or submarine.Captain Mark Prokopius, the commanding officer of Notre Dame NROTC, described the purpose of summer training as exposing midshipmen to both life in the Navy and to leadership decisions that are necessary as an active-duty officer.“When they’re on cruise, they’re actually on active duty and subject to all the active duty rules,” he said. “It builds valuable experience to see from the enlisted perspective on the second-class cruise, and then [on the first-class cruise] to see from the officer’s perspective, who is the leader in front of those enlisted men.”All midshipmen are required to complete summer training unless exempted by a conflict or disciplinary probation.Kathleen Halloran, a second-class midshipman and a junior at Saint Mary’s, said she knew she wanted to serve her country from a young age after being inspired by her grandfather, a Marine veteran. Halloran said her summer experience — staying aboard a submarine — was enriched by the presence of women in positions of power. “It was incredible being on the submarine surrounded by brilliant female officers, as female officers are currently not very common,” she said.Halloran said her favorite part of the summer was spending time with five other women, who she said she got to know quite well, on the submarine.Aboard the aircraft carrier U.S.S. Ronald Reagan, Saint Mary’s junior Megan Mullaney furthered her interest in surface warfare. Mullaney spent each week shadowing a new person, but she said her favorite moments were spent shadowing flight deck control.“It was really cool to get the opportunity to be on the flight deck when people were taking off and landing,” she said.While the month spent aboard the ship was full of new learning opportunities, Mullaney said it came with challenges as well. She said her most challenging experience was constantly feeling in the way of others.“Your job is to shadow and observe but you still feel you’re in the way because you are not doing a certain job,” Mullaney said.Notre Dame sophomore and third-class midshipman Michael Terranova spent 19 days on an Ohio-class submarine embarking from Pearl Harbor, Hawaii. While his primary preference is in aviation, he said the cruise provided a valuable exposure to life in the Navy.“It showed me that if the Navy tells me I have to do it, I can,” he said. “It was also a really informative experience to learn the submarine’s role in the navy, but I think most importantly it showed me what life in the Navy is like … I was able to see people doing their jobs, and I got at tiny picture of what life as an officer is like.”Notre Dame senior and first-class midshipman Thomas Hart was assigned to Naval Air Station Lemoore in California. While previously interested in naval aviation, he said the experience, in which he was able to fly in an F-18 fighter jet, take-off from an aircraft carrier at sea and briefly pilot a jet, confirmed his choice to work towards becoming a pilot.“It not only provided me with those flight experiences to see how cool flying was, but even more important was seeing how the community operated and seeing how the pilots interacted with each other,” he said. “The pilots I worked with were great guys and loved their jobs. I saw myself in that community. It’s really important to see if you fit in with the people, so I think that’s the right community for me.”Tags: Mark Prokopius, Naval ROTC, NROTC, ROTC, summer traininglast_img read more

first_imgMr. George Arnold Harlow, age 78, of Vevay, Indiana, entered this life on February 3, 1940, on Tapp’s Ridge at their home in Switzerland County, Indiana. He was the loving son of, Ollie L. and Mary E. (Bennett) Harlow Reynolds. George was raised in Switzerland County where he attended high school. George was united in marriage on June 29, 1968, at the Ruter Chapel United Methodist Church in Vevay, Indiana, to Donna Jean Coy and to this union arrived a daughter, Angela to bless their home. George and Donna shared nearly 50 years of marriage together until his death. George was employed for Schenley Distillery in Lawrenceburg, Indiana for 25 years, until 1988 when the company shutdown. He was later employed as the night security officer for the Ogle Haus in Vevay, Indiana, for several years and for Lee Bliss General Store in Markland, Indiana. George was employed as the custodian for the Switzerland County Courthouse, retiring in April 2010. George resided in Cincinnati, Ohio from 1968 – 1973 and later moved back to the Switzerland County community where he resided until his passing. George enjoyed farming, raising tobacco and hay for many years, fishing and watching the Cincinnati Reds. But most of all, George enjoyed spending time with his three grandchildren and attending their academic activities as well as their sporting events. George passed away at 11:48 a.m., Wednesday, February 21, 2018, at the Hospice Care of Saint Elizabeth in Edgewood, Kentucky. George will be deeply missed by his loving wife of nearly 50 years, Donna Jean (Coy) Harlow of Vevay, IN; his daughter, Angela Todd and her husband: David of Vevay, IN; his grandchildren, Logan, Brooke and Cooper Todd; his brothers, Robert Harlow of Cincinnati, OH and Ollie Harlow, Jr. of Cincinnati, OH; his father-in-law and mother-in-law, Robert Allen and Naomi Jean (Slack) Coy of Milroy, IN; his brothers-in-law and sisters-in-law, Carolyn Sue and Stan Whalen of Ross, OH, Glenda Lou and Jim Brown of Middletown, OH, Joan and Don Wipf of Collinsville, OK, Doris Jan and Terry Young of Rising Sun, IN, Benita Colleen and Bill Kaffenberger of Hidden Valley Lake, Lawrenceburg, Indiana, Melanie and Terry McQueen of Rushville, IN, Louis Allen Coy of Florence, IN, Nathan Lynn Coy of Florence, IN and Jonathan Edward and Lisa Coy of Greensburg, IN and his several nieces, nephews and cousins.He was preceded in death by his parents, Ollie L. Harlow, Sr., died January 17, 1940 and Mary E. (Bennett) Harlow Reynolds, died December 3, 1975 and his sister, Ella Mae Peelman, died March 18, 2005.Funeral services will be conducted Monday, February 26, 2018, at 11:00 am, at the Haskell & Morrison Funeral Home, 208 Ferry Street Vevay, Indiana 47043. Interment will follow in the Hastie Cemetery, Markland, Indiana.Friends may call 5:00 pm – 8:00 pm, Sunday, February 25, 2018, at the Haskell & Morrison Funeral Home, 208 Ferry Street Vevay, Indiana 47043. Memorial contributions may be made to Hospice Care of Saint Elizabeth or Keeping Pace Cancer Fund % CFSCI. Cards are available at the funeral home.last_img read more

first_imgAfter a disappointing loss to Oregon, the USC women’s basketball team looks to bounce back this week against two of the top teams in the Pac-10.USC (13-7, 7-2) kicked off the second half of its conference schedule with road games against California and No. 2 Stanford. The Women of Troy beat Cal (11-9, 5-4) earlier this season on a last-second 3-pointer by sophomore guard Ashley Corral.“We had a tough game against Cal here at home and they’re probably coming out to avenge that loss,” senior guard Hailey Dunham said. “We have to go in with a new focus and correct the things we didn’t do as well the first time we played them.”One thing USC needs to figure out is a way to slow down the Golden Bears’ inside-out combination of freshman forward/center DeNesha Stallworth and redshirt senior guard Alexis Gray-Lawson. In the first game between the two teams this season, the duo combined for 50 points.“After that we switched up our post defense,” USC assistant coach Mary Wooley said. “We’re really challenging our [bigs] to play better defense because they let a freshman get 30 points on them.”USC must also be ready for Cal’s pressure defense. The Women of Troy turned the ball over 18 times against Oregon and spent practice discussing how to overcome it.“A lot of it comes down to recognizing where we need to be on the basketball floor,” Wooley said. “We try and tell them one thing that counteracts pressure is calmness. If you stop and slow down, the pressure can’t be as effective.”The road does not get any easier for the Women of Troy after that. USC battles No.2 Stanford (19-1, 9-0) on Sunday in a game that will be televised locally. Stanford won handily at the Galen Center last month and has yet to be challenged this season in the Pac-10.“Every game that we play we want to measure ourselves against Stanford,” Wooley said. “If we can come out and compete with them I think we can surprise some people.”This weekend could feature the debut of redshirt junior guard Jacki Gemelos. The former McDonald’s All-American has been cleared for action after sitting out the last three seasons with knee injuries.Other members of the team are dealing with injury concerns as well. Corral, who leads the team in scoring, sat out of practice on Monday with a sore heel.“Everybody’s got bumps and bruises, but I don’t think we’re beat down at all,” Dunham said. “We’re coming out fired up about the Oregon loss.”The Women of Troy play Cal at 7 p.m. tonight. They take on the Cardinal at 1 p.m. Sunday.last_img read more

first_imgDownload the hearZA app and test yourself and two friends’ hearing via your smartphone. The innovation is from a South African team and is used globally.It’s a world first – a smartphone app that lets people test their hearing, says lead researcher Prof De Wet Swanepoel. The app was created by a South African research team and it is being tried all over the world. (Images supplied)Melissa JavanMore than 40,000 hearing tests have been done with a hearing app created by a South African team of researchers. The hearScreen app, provided on a smartphone, is being used in 25 countries worldwide, including Ethiopia, Australia and Guatemala.Because of its success, the South African public can now use the hearing detecting app, hearZA.Speaking on talk radio station CapeTalk, Prof De Wet Swanepoel of the department of speech-language pathology and audiology at the University of Pretoria called the hearZA app “a super computer you have in your pocket”. It helps anyone who is 16 or older to test their hearing.Why the appHearing loss is an invisible epidemic, says Swanepoel, the lead inventor of the app. According to the professor, more than three million South Africans suffer from permanent, disabling hearing loss.“Since it’s invisible, people don’t see it or appreciate the effects of hearing loss. In children it is a major reason for poor speech and language development and of academic failure as a result,” says Swanepoel.“In adults it is associated with significant socio-emotional difficulties, depression and a threefold increased risk of dementia.”Watch the hearScreen researchers talk about the social impact of the app and why people should care about hearing loss:The hearScreen appSwanepoel explains the hearScreen app is provided on a smartphone with a calibrated headphone. This is to allow an accurate hearing test from an Android smartphone according to international standards. “It is not a consumer app but is provided preloaded on specific smartphones with a headphone.”The hearScreen project started in 2013 but its beta launch was on World Hearing Day on 3 March 2016, he says. “(By beta launch) we mean that it is not the final product launch. We have launched to interested parties but based on experiences are still refining it for a final product launch in 2017.”Prof De Wet Swanepoel with five-year-old patient Keziah Maisiri.The app is used in various settings from screenings in schools, early childhood development centres and primary health care clinics, to monitoring TB patients for drug-induced hearing loss and monitoring hearing status in occupational health settings, Swanepoel explains.Outcome of the testing“Based on the geolocation captured for each test and the integrated cloud-based data solution, a text message or email can be sent to the person tested or their parents providing the test outcome and closest hearing health provider in cases of a referral.”The noise check score gives a ratio between 1 and 9. “The test provides a signal to noise ratio for an individual. In essence this is an indicator of someone’s ability to understand speech in the presence of background noise.“The app converts this to a personal hearing score that people can use to monitor their hearing over time.”Prof De Wet Swanepoel says more than 40,000 screen testings have been done worldwide using the hearScreen app.The hearZA appSwanepoel says hearZA is the downloadable Android and iOS application. The app, developed and validated by the University of Pretoria, provides every user with a free hearing test.The two-minute test, sponsored by Sivantos, Oticon and the Ear Institute, requires users to listen to simple digits in noise. Once finished, the user receives their hearing score.hearZA is released by hearScreen, which is supported by The Innovation Hub under its Maxum Business Incubator and mLab Southern Africa.This national hearing test for South Africa provides a free hearing test, says Swanepoel. “It also links patients to their closest hearing health providers based on geolocation with in-app support to make a decision regarding follow-up.”It gives everyone a three test-crediting, Swanepoel told CapeTalk.Every download includes three free test credits, which is one test per person. “After that test credits can be purchased,” says Swanepoel. “A year after the last test, a person is credited with another free test credit to monitor their hearing profile annually.”A Brand South Africa journalist downloaded the hearZA app using an Android cellphone. It was 21 megabytes to download and 0.4 megabytes to do the testing. The journalist got her hearing test results following her test.Would you like to use this article in your publication or on your website? See Using Brand South Africa materiallast_img read more

first_img Mr. Holness said he is very pleased that the National Commercial Bank (NCB) and its Capital Market venture saw it fit to finance a company like GWest to realise its dream of building an expansive one-stop shop medical facility in Montego Bay. Prime Minister, the Most Hon. Andrew Holness, says Jamaica’s economic climate is so positive that banks are once again lending money for productive enterprises. Mr. Holness added that it is also good business sense that GWest is now looking at going on the Junior Stock Exchange and giving the public a chance to be a part of its ownership. Prime Minister, the Most Hon. Andrew Holness, says Jamaica’s economic climate is so positive that banks are once again lending money for productive enterprises.Delivering the keynote address at the official opening of the GWest Medical Centre in Fairview, Montego Bay, on November 2, Mr. Holness added that it is indeed a good sign for the country’s economic future, and that the Government sees it as a strong vote of confidence for the policies that are in place.“The data are showing that loans for productive enterprises are increasing, not just for consumption but for productive enterprises. That is a very good sign for growth,” the Prime Minister noted.Mr. Holness said he is very pleased that the National Commercial Bank (NCB) and its Capital Market venture saw it fit to finance a company like GWest to realise its dream of building an expansive one-stop shop medical facility in Montego Bay.“For providing the investment for this facility, the Government is very pleased and we want to call out NCB and NCB Capital Market for taking the risk and providing the loan to make this possible,” the Prime Minister said.“It is also a vote of confidence in the economic direction that banks are now willing to look at investments and calculate the risk and absorb them in their portfolio, and actually lend,” he added.The Prime Minister said it was not that long ago when the criticism was that banks were reluctant to lend money to high-risk investments, preferring to offer loans to businesses that were deemed “riskless”.“It is a very good look for our economy when the banks are willing to finance companies like GWest. We certainly need these kind of investments to keep our economy growing,” he argued.Mr. Holness added that it is also good business sense that GWest is now looking at going on the Junior Stock Exchange and giving the public a chance to be a part of its ownership.“I would encourage Jamaicans to try and own a piece of GWest by way of the stock market,” the Prime Minister said.The GWest Centre was established by a group of Jamaican medical and business professionals. It is housed in a modern multipurpose commercial complex and provides a wide range of high-quality medical services in the same location. Story Highlightslast_img read more

first_imgBy Jorge BarreraAPTN National NewsOn Saturday afternoon, a Taseko Mines convoy of trucks and equipment was stopped by an RCMP cruiser on the gravel Nemiah Valley road in British Columbia’s interior.Xeni Gwet’in Chief Marylin Baptiste pulled up alongside the convoy and the RCMP cruiser to inform them that the Taseko contractors and employees would not be welcome on Tsilhqot’in nation territory.“We had discussions back and forth and the company talked to the RCMP and the RCMP talked to me and said they were agreeing to turn around,” said Baptiste, whose community is one of six that make up the Tsilhqot’in nation.The company informed the RCMP earlier in the day that Baptiste would be waiting for the convoy and two officers from the RCMP Alexis Creek detachment went to the area to “keep the peace,” said Sgt. James Anderson.Baptiste said she doesn’t know how the company knew she would be waiting, but Tsilhqot’in members had been keeping an eye on the company’s movements.“I knew that their dozer sitting in Williams Lake had moved and I had every reason to believe they were on their way,” said Baptiste.This was the second weekend in a row a Taseko convoy was turned back on Nemiah Valley road.On Nov. 6, a Taseko convoy was stopped by Baptiste and others. The company claims in a court filing that someone threatened to set fire to the equipment.Nemiah Valley road leads to the planned site of Taseko’s 35 square-kilometre, open-pit gold and copper Prosperity Mine project, which is about 125 kilometres southwest of Williams Lake, B.C.The incidents on Nemiah Valley Road could foreshadow more explosive confrontations.Taseko has been trying for years to dig up the area for gold and copper and it has the full backing of the provincial government.The Tsilhqot’in oppose the project and view it as a threat to their very existence.And the RCMP is aware of the rising tensions.“We at the Alexis Creek RCMP detachment remain neutral on this issue. We do not want to do anything to create a negative impact on our relations with our local First Nations communities,” said Anderson. “The RCMP officers in the command structure above me are well aware of the issue going on at this time.”Taseko has since gone to B.C. court seeking a restraining order against Baptiste and other individuals that try to stop the company from entering the territory, according to a company statement.Taseko could not be reached for comment.The Tsilhqot’in in turn filed for a court injunction to stop Taseko from entering the territory to drill, build roads or excavate test pits until a separate court action comes to a conclusion.The Tsilhqot’in have filed for a judicial review to quash the B.C. provincial government’s decision to give Taseko permits allowing the company to dig the pits and clear timber for roads without first consulting the First Nations whose lands would be impacted.Baptiste said Taseko is planning to drill 59 sites and build 23 kilometres of road and trail while clearing about 1,500 cubic metres of timber.“That is a tremendous amount in destruction of our wetlands in the territory,” said Baptiste.Taseko says it needs to do the work to gather data for the environmental assessment it needs to present to the Canadian Environmental Assessment Agency (CEAA) which is reviewing its controversial Prosperity Mine project for a second time.The federal cabinet rejected the Prosperity project last year after the agency concluded the project would have a devastating environmental impact on fish habitat and grizzly bear populations in the region.Former environment minister Jim Prentice said at the time that the agency’s report was the “most condemning” he had ever seen. Prentice said the project threatened not only Fish Lake, which Taseko planned to drain, but the entire ecosystem flowing from the lake.Prentice, however, said the company was free to try again.The federal government recently directed the CEAA to review a second proposal from the company.This time the company says it has no plans to drain Fish Lake, but will still destroy Little Fish Lake and parts of Fish Creek by turning them into waste dumps.The company claims it will preserve Fish Lake and its surrounding area while also reducing the mine’s impact on grizzly bear habitat.The company has said it would spend an additional $200 million to relocate its tailings dam and move mine waste around Fish Lake to other locations.Fish Lake, Little Fish Creek and Little Fish Lake are at the headwaters of the Taseko River systems which is one of Canada’s main six producers of sockeye salmon. The system also supports Chinook salmon and endangered stocks of steelhead trout.Taseko said the project will generate over $1 billion in tax revenues to federal and provincial coffers over the 20 to 30 year life-span of the mine. The company said the mine will also generate $340 million in GDP annually and create hundreds of jobs.Taseko has been trying since the mid-1990s to get the mine approved, but has faced resistance, in particular from the federal Fisheries and Oceans department.Baptiste said the Tsilhqot’in feel frustrated the project keeps on finding new life.“We have tried working through the processes respectfully,” said Baptiste. “There is always this uproar about blockades or this or that, but it is not our people who are forcing that, who are choosing such action. It is the federal and provincial governments and industry that is pushing people to no other option.”Baptiste said stopping the Prosperity project is a matter of cultural survival and honour directly linked to the Chilcotin War of 1864.As it is today, the conflict was over gold.Already reeling from an outbreak of smallpox spread by infected blankets sold by traders, the Tsilhqot’in fought to stop the planned construction of a toll wagon road connecting the nascent colony’s Pacific coast to the newly discovered gold fields in the interior.The Tsilhqot’in launched a guerrilla campaign and eventually stopped the road, but it came at a high price. At least 19 European settlers were killed and six Tsilhqot’in chiefs were hanged.“I’m getting flashbacks of 1864,” said Baptiste. “Our war leaders defended our way of life and stopped a road crew. Today, nothing has changed…I am hoping we don’t get to that point.”Baptiste says the Tsilhqot’in will stop the mining project at all costs.“If it weren’t for our war leaders back then, we wouldn’t be who we are,” she said. “That is our honour. We cannot allow the destruction of our land that provides for us.”[email protected]last_img read more

first_imgSchematic diagram of MS NPs serving as an intratumoral DOA for specific cancer-starving therapy. Activated by the acidic tumour microenvironment, the MS NPs produce reactive silane to give rise to an efficient deoxygenation effect and produce in situ SiO2 blockers in tumour blood capillaries, which subsequently prevent undesired reoxygenation. The deoxygenated tumour with no further oxygen supply will suffocate in the absence of the necessary energy metabolism. MS NP here is the PVP-modified Mg2Si nanoparticles. Journal information: Nature Nanotechnology New nanoparticle-based contrast agent that is pH dependent More information: Chen Zhang et al. Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy, Nature Nanotechnology (2017). DOI: 10.1038/nnano.2016.280AbstractA material that rapidly absorbs molecular oxygen (known as an oxygen scavenger or deoxygenation agent (DOA)) has various industrial applications, such as in food preservation, anticorrosion of metal and coal deoxidation. Given that oxygen is vital to cancer growth, to starve tumours through the consumption of intratumoral oxygen is a potentially useful strategy in fighting cancer. Here we show that an injectable polymer-modified magnesium silicide (Mg2Si) nanoparticle can act as a DOA by scavenging oxygen in tumours and form by-products that block tumour capillaries from being reoxygenated. The nanoparticles are prepared by a self-propagating high-temperature synthesis strategy. In the acidic tumour microenvironment, the Mg2Si releases silane, which efficiently reacts with both tissue-dissolved and haemoglobin-bound oxygen to form silicon oxide (SiO2) aggregates. This in situ formation of SiO2 blocks the tumour blood capillaries and prevents tumours from receiving new supplies of oxygen and nutrients. Citation: Study shows that nanoparticles serve as a good tumor deoxygenation agent (2017, January 20) retrieved 18 August 2019 from (—One target therapy in cancer research is to suffocate the tumor. Cells need oxygen to survive so researchers have focused on methods for cutting off the blood supply to the tumor. Very little research has involved the direct removal of oxygen within the tumor. Part of the reaction mechanism involves the formation of Si4-, which is highly sensitive to acid. This is important because the tumor environment tends to be acidic compared to normal tissue (pH~6.4), and pH sensitivity may help with tissue specificity. To investigate the pH sensitivity of their deoxygenation agent, Zhang et al. placed their nanoparticles in a dialysis bag, which were then immersed in buffer solutions of varied pH values within closed tubes. In acidic conditions, the nanoparticles irreversibly decreased the level of oxygen, but were unreactive in neutral pH. Furthermore, SiO2 aggregates formed in situ that served to block a simulated capillary.Additional studies demonstrated that the MgSi2 nanoparticles demonstrated very little cytotoxicity until they encountered the acidic environment of the cancer cell. Using MCF-7 human breast adenocarcinoma cells, Zhang et al. observed that the combination of acid and nanoparticles led to cell efficient hypoxia. Furthermore, cell proliferation decreased, which is likely due to mitochondrial damage from deoxygenation.In vivo studies involving bilateral 4T1 xenotumor-bearing mice demonstrated that Mg2Si nanoparticles served as efficient deoxygenation agents. Each mouse was injected with the nanoparticle deoxygenation agent in the right tumor and with saline solution as a control in the left tumor. Measurements of blood oxygen saturation levels after ten minutes showed little change in the control tumor and a drastic reduction in oxygen in the test tumor. Oxygen reduction continued for three hours in the tested tumor until tests on both the hemoglobin-bound oxygen and blood oxygen showed complete depletion within the tumor. Notably, PET/CT images show that hypoxia occurred within the tumor and not in the surrounding tissues.Additional observations from the in vivo study showed that the tumors that received Mg2Si nanoparticles demonstrated a slower growth rate compared to controls and after twenty-four hours, although cell proliferation was not slowed down as significantly as in the in vitro studies. These cells showed evidence of fibrosis, necrosis, and apoptosis. Additionally, magnesium was quickly eliminated from the body while silicon was eventually eliminated.Overall, this research provides a compelling proof-of-concept for the use of PVP-modified Mg2Si nanoparticles as potential candidates for use as a tumor-targeted deoxygenating agent. The authors point out that future research would involve exploring surface modifications of the nanoparticles to tailor the length of time the nanoparticles can travel through the blood stream. To this end, a group of researchers from the Shanghai Institute of Ceramics, Chinese Academy of Sciences and the East China Normal University have developed a deoxygenation agent using polyvinyl pyrrolidone modified Mg2Si nanoparticles. This agent is pH sensitive, efficiently consumes oxygen, and one of the products of oxygen consumption also forms aggregates that could potentially block blood vessels. Preliminary mouse studies show tumor hypoxia and good biocompatibility. Their work appears in Nature Nanotechnology.There are several important qualities for a good tumor-starving agent. For one, the agent must be biocompatible which negates the use of heavy metals for oxygen absorption. Additionally, the agent must be efficient at deoxygenation and serve as a long-term oxygen scavenger including preventing re-oxygenation of deoxygenated tumors through undamaged blood vessels. And, as always, any cancer treatment needs to target tumors without damaging healthy tissue, and the agent should be easily injectable by syringe.In the current research, Zhang et al. developed polyvinyl pyrrolidine (PVP)-modified Mg2Si nanoparticles that have several of the qualities for a good tumor-starving agent. Importantly, the main components, magnesium, silicon dioxide, and water are biocompatible. Additionally, the reaction mechanism forms a highly reactive O2 scavenger, SiH4, which serves to make these nanoparticles highly efficient at scavenging oxygen.In order to make injectable nanoparticles, Zhang et al. developed a self-propagating high-temperature synthesis in an oxygen-argon atmosphere. This allows the nanoparticles to remain dispersed in the liquid, rather than form clusters, so that they are injectable into tissue. This synthesis takes advantage of the formation of MgO by-product that halts the continual formation of Mg2Si aggregates. © 2017 Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more