first_imgAs well as being harassed by the police, journalists are also being targeted and attacked by demonstrators throughout the country, especially in rural regions, where they are suspected of being corrupt and working for the government. to go further “President Moreno’s administration must stop censoring and obstructing journalists’ work and instead guarantee their safety throughout Ecuador,” said Emmanuel Colombié, the head of RSF’s Latin America bureau. “At this troubled time for Ecuador, the freedom to inform is more essential than ever for the entire population. The authorities must also quickly investigate and identify those responsible for the many attacks and threats, both physical and online, against the media all over the country.” News EcuadorAmericas Condemning abusesProtecting journalists Freedom of expressionViolence RSF_en Coronavirus “information heroes” – journalism that saves lives Two months before Assange’s extradition hearing, RSF calls for his release on humanitarian grounds and for US Espionage Act charges to be dropped In this extremely tense climate, journalists covering the protests have been targeted by both police and protesters. Police violence and arbitrary arrests of media personnel have been reported in many of the country’s major cities. The victims of protester hostility have included freelancer Andrea Orbe Saltos, William Rivadeneira of Cable Mágico, Carlos López of Macas News, César Correa of Radio Shalom, Yerson Palma of La Razón and Univision Arkansas, and reporters for Radio Caracol. The next day, Radio Olímpica’s Leyda Ángulo and TV Cisne’s Geovanny Astudillo were arrested and held for 12 hours without being given any explanation. Iván Lozano of the student TV channel Udla was also arrested by police officers, who destroyed his equipment. News EcuadorAmericas Condemning abusesProtecting journalists Freedom of expressionViolence In the city of Puyo, Marlon Santi and Jairo Gualinga of Lanceros Digitales were arrested and told to stop filming the protests. They were also brought before a judge but were finally released without being charged. Receive email alerts April 10, 2020 Find out more RSF is in the process of documenting many other cases. Organisation Camila Martínez, a member of the media department of the Ecuadorean Confederation of Indigenous Nationalities (CONAIE), was arrested while covering protests in Guayaquil on 7 October and was sentenced to five days in prison on charges of “mistreating, insulting and attacking law enforcement officers.” SOURCE: Cristina VEGA / AFP Coronavirus: State measures must not allow surveillance of journalists and their sources Interior minister María Paula Romo and President Moreno have repeatedly apologized for these abuses and have called on the police to respect the work of journalists and ensure they are able to cover demonstrations. But, given the scale and intensity of the protests, the government needs to make sure these instructions reach the police everywhere, including  in regions far from the big cities, where journalists are particularly vulnerable. June 15, 2020 Find out more Follow the news on Ecuador News October 10, 2019 Media targeted in Ecuador’s deepening crisis Ecuador is ranked 97th out of 180 countries in RSF’s 2019 World Press Freedom Index. Many media outlets, including the newspaper El Comercio and the news website GK, have reported feeling very vulnerable and they say their reporters lack the protective equipment needed to cover the crisis properly. Fundamedios, a local press freedom NGO, counted 59 attacks against journalists across the country in six days. These large-scale protests began when President Lenin Moreno announced on 2 October that his government was ending fuel subsidies in effect for nearly 40 years, causing a sharp hike in fuel prices. The protests led Moreno to decree a state of emergency the next day and to move the government from the highland capital, Quito, to the port city of Guayaquil. Several radio and TV stations, such as Radio Centro Ambato, have been prevented from broadcasting by power cuts coordinated by the authorities. The headquarters of Quito-based Radio Pichincha Universal were raided and searched by police and representatives of the prosecutor’s office, who told its journalists that its radio frequency would be withdrawn if they did not change their editorial policies. Help by sharing this information December 24, 2019 Find out more In Quito, two photographers with the newspaper El Comercio and several reporters for other media outlets including El Expreso, El Universo and Primicia were beaten by police while covering protests on 3 October. Two other journalists, Mateo Flores of Manzanas and Nicole Villafuerte of Vozes, were tear-gassed and arrested the same day, and were held for 27 hours. News Reporters Without Borders (RSF) calls on the authorities to guarantee journalists’ safety throughout Ecuador after more than a week of very worrying attacks on reporters by both police and demonstrators during violent anti-government protests, strikes and blockades that are continuing all over the country. last_img read more

first_img Community News First Heatwave Expected Next Week faithfernandez More » ShareTweetShare on Google+Pin on PinterestSend with WhatsApp,Virtual Schools PasadenaHomes Solve Community/Gov/Pub SafetyPASADENA EVENTS & ACTIVITIES CALENDARClick here for Movie Showtimes Name (required)  Mail (required) (not be published)  Website  Community News Business News Your email address will not be published. Required fields are marked * Make a comment Pasadena and the rest of southern California are expected to experience stormy weather again starting Thursday through the weekend, as a series of storms comes through the forecast area.The strongest storm, says the National Weather Service, will occur Friday through early Saturday and bring “damaging winds, heavy rains and the potential for widespread flooding.”“This will be the beginning of a significant weather pattern change across Southern California over the next several days as several disturbances will affect the forecast area into next week,” the NWS said Wednesday in a Forecast Discussion, referring to the first of a series of approaching storms.Thursday could see some patchy fog before 10 a.m. then will be partly sunny, with a high near 69. In the afternoon, a 30 percent chance of rain is possible especially after 4 p.m. with a south wind at five to 10 miles per hour.This first wave of moisture will bring in modest rainfall, the NWS says.Serious rain should start Thursday night, becoming heavy mainly after 4 a.m. The chance for rain at this time is 80 percent. Lows will be around 53, and the southeast wind could gust as high as 15 mph.“The second and most dynamic storm system Southern California has seen in a while will then begin to approach from the west with a classic Atmospheric River component,” says the NWS.Friday will have a 90 percent chance of rain and possibly a thunderstorm producing heavy rainfall. Rainfall rates of one inch per hour are expected with this storm system, and the southeast wind could gust as high as 30 mph.“This will be a very dangerous storm, with the peak of the heavy rain expected early Friday morning through Friday night into early Saturday morning,” says the NWS “People need to take this upcoming storm very seriously.”By Friday night, the chance of rain is at 100 percent with possibly a thunderstorm. Lows will be around 51.Saturday will still be rainy but the upper low that has been the source of heavy rain is expected to slide south bringing along much of the rain energy with it. Additionally, winds will weaken considerably and shift to the northwest.“While there still will be some showers around they`ll be pretty scattered and generally on the light side and more prevalent across the higher terrain,” the NWS said. “The upper low will move east Saturday night into Sunday with very weak ridging developing Sunday. This should lead to a drier and warmer day Sunday with maybe just some lingering mountain showers.”Aside from a slight chance of showers, Sunday should be mostly cloudy, with a high near 63.Here’s an overview of the forecast:Thursday: A 30 percent chance of rain after 4pm. Patchy fog before 10am. Otherwise, partly sunny, with a high near 69. South wind 5 to 10 mph.Thursday Night: Rain, mainly after 4am. The rain could be heavy at times. Low around 53. Southeast wind 5 to 10 mph, with gusts as high as 15 mph. Chance of precipitation is 80%.Friday: Rain and possibly a thunderstorm. Some of the storms could produce heavy rainfall. High near 57. Breezy, with a southeast wind 15 to 20 mph, with gusts as high as 30 mph. Chance of precipitation is 90%.Friday Night: Rain and possibly a thunderstorm. Some of the storms could produce heavy rainfall. Low around 51. Breezy. Chance of precipitation is 100%.Saturday: Rain likely. Mostly cloudy, with a high near 61. Chance of precipitation is 70%.Saturday Night: A chance of rain. Mostly cloudy, with a low around 50.Sunday: A slight chance of showers. Mostly sunny, with a high near 63.Sunday Night: Partly cloudy, with a low around 50.Washington’s Birthday: A slight chance of rain. Mostly cloudy, with a high near 62.Monday Night: A chance of showers. Mostly cloudy, with a low around 50.Tuesday: Mostly sunny, with a high near 63. Pasadena’s ‘626 Day’ Aims to Celebrate City, Boost Local Economy Get our daily Pasadena newspaper in your email box. Free.Get all the latest Pasadena news, more than 10 fresh stories daily, 7 days a week at 7 a.m.center_img HerbeautyThese Are 15 Great Style Tips From Asian WomenHerbeautyHerbeautyHerbeautyUnapologetic Celebs Women AdoreHerbeautyHerbeautyHerbeauty10 Questions To Start Conversation Way Better Than ‘How U Doing?’HerbeautyHerbeautyHerbeautyBohemian Summer: How To Wear The Boho Trend RightHerbeautyHerbeautyHerbeauty6 Strong Female TV Characters Who Deserve To Have A SpinoffHerbeautyHerbeautyHerbeautyIs It Bad To Give Your Boyfriend An Ultimatum?HerbeautyHerbeauty Home of the Week: Unique Pasadena Home Located on Madeline Drive, Pasadena Top of the News Subscribe top box 1 More Rain to Hit Pasadena Hard Late Thursday Published on Wednesday, February 15, 2017 | 11:23 am 4 recommended0 commentsShareShareTweetSharePin it More Cool Stuff EVENTS & ENTERTAINMENT | FOOD & DRINK | THE ARTS | REAL ESTATE | HOME & GARDEN | WELLNESS | SOCIAL SCENE | GETAWAYS | PARENTS & KIDS Pasadena Will Allow Vaccinated People to Go Without Masks in Most Settings Starting on Tuesday last_img

first_img June 1, 2002 Regular News June 1, 2002 Letters Same As It Ever Was Regrettably, it seems some things never change. When I was the executive director and general counsel of The West Virginia State Bar in the mid-1970s, more than 80 percent of the complaints against our members involved failure to communicate or inadequate communications with clients. And, my fellow members of the National Organization of Bar Counsel reported similar results.According to the article “ACAP helps lawyers and clients sort through their differences” in the April 15 News, “program statistics show that a majority of caller complaints boils down to a lack of communication between attorney and client.” It is ironic that American’s “mouthpieces” are all too often silent when it comes to those they represent. Duke Nordlinger Stern St. Petersburg Southern Legal Counsel There is an old saying which goes something like “there is no limit to what one can accomplish if one doesn’t mind who gets the credit.”Alice Nelson was kind enough to send us a copy of an article in the March 15 News on Southern Legal Counsel. I’d like to add a bit of background to the founding of SLC.The McIntosh Foundation was started by my parents, both Republicans, in New York in 1949. Upon graduation from high school in 1952, my present was a lifetime membership in the Sierra Club.In 1971, upon the death of my mother, I became president of the foundation. A year later, my wife and I moved to Palm Beach County from New York, bringing the foundation with us. At that point, we were a very small foundation casting about on how we might “add to the whole.”In the summer of 1971, we met a young man (John Adams) who, with the help of a senior partner in Simpson, Thatcher (NYC) and the Ford Foundation, had started, along with others, a public interest law firm called the Natural Resources Defense Council. He suggested that by using the law, we might leverage our funds to accomplish more than our modest means might reasonably be expected to accomplish.Consequently, we gave a multiple-year grant to NRDC which, at that point, doubled their budget. Shortly thereafter, we were approached by James Moorman, then executive director of the Sierra Club Legal Defense Fund (now Earth Justice) and subsequently gave them a grant for other conservation/environmental work.Early in 1972, we read of the Nixon administration’s impounding of congressionally approved funds. This not only seemed wrong to us (bad public policy) but also appeared to be a perfect type of public interest issue for litigation.We first approached several large law schools in the Northeast about taking on the project. However, we soon got turned off by their “be happy we are even willing to let you in the door” reception to our ideas.At that point my wife, who is a graduate of the University of Florida, suggested that rather than butting our heads against the likes of Harvard, Yale, Columbia, et al., I talk to her alma mater. Fortunately I listened to her, called Dick Julin, made an appointment, and subsequently met with him to explain the project we had in mind.Fortunately the timing couldn’t have been better. At that point, Julin had been looking for a vehicle to create a clinical education project at the University of Florida Law School, had the “perfect” fellow to run it (Jon Mills), and thought the impoundment project (basically a legal v. a political issue) as good as any to start with.In 1972, we made a grant to the law school of $87,000 (over $400,000 over the following years) and the Center for Governmental Responsibility was underway.The eventual founding of Southern Legal Counsel as an offshoot of the Center for Governmental Responsibility was inevitable (i.e. , one can’t take a handful of bright, dedicated students, get them involved in interesting issues, and not expect they are going to want to see/participate in some “action”). Michael A. McIntosh Alice K. Nelson Washington, D.C.last_img read more

first_imgArsene Wenger reveals why he blocked Robin van Persie’s request to rejoin Arsenal from Man Utd Arsene Wenger reluctantly sold Robin van Persie to Manchester United in the summer of 2012 (Picture: Getty)Arsene Wenger has revealed he rejected Robin van Persie’s request to rejoin Arsenal from Manchester United.The former Netherlands international scored over a century of goals for the Gunners during his eight years in north London but infamously defected to Old Trafford in the summer of 2012.Van Persie had grown tired of seeing many of his former teammates depart and enjoy success elsewhere, without seeing Arsenal reinvest the money they earned from the sales of Samir Nasri and Cesc Fabregas in high calibre replacements. Under Sir Alex Ferguson’s guidance, Van Persie’s goals helped fire United to the Premier League title in his first season, but his form declined following the legendary Scotsman’s sudden departure.AdvertisementAdvertisementADVERTISEMENTNeither David Moyes or Louis van Gaal were able to help Van Persie hit the heights he did while Ferguson was at the helm, and he was eventually sold to Fenerbahce at the end of his compatriot’s first season in charge. Comment Advertisement Metro Sport ReporterWednesday 14 Oct 2020 11:28 amShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link625Shares Advertisement Robin van Persie’s goals helped Man Utd win their last Premier League title in 2013 (Picture: Getty)In his new book ‘Arsene Wenger, My Life in Red and White’, Arsenal’s former manager revealed Van Persie had contacted him to discuss the possibility of a return to the Emirates Stadium but the Frenchman felt any comeback would be ‘impossible’ to facilitate. He wrote: ‘In 2012, he announced his intention not to extend his contract. All the big clubs were courting him. I sold him to Manchester United.‘The supporters were angry with me for this but we could not match the offer. I managed to negotiate his departure for £24million, which was a huge amount at the time for a player with a year left on his contract. I had only the interest of the club in mind. More: Manchester United FCRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starNew Manchester United signing Facundo Pellistri responds to Edinson Cavani praiseEx-Man Utd coach blasts Ed Woodward for two key transfer errors‘My relationship with Alex Ferguson and Manchester United had improved by then, but every transfer is a polite game of poker where you attempt to give not anything away. ‘Van Persie had a fantastic first six months at Old Trafford: he put the team on track for the Premiership title and made it even more difficult for us. But after three years of the four that he signed for, he was injured and Ferguson (sic) sold him to the Turkish club Fenerbahce.‘He called me because he wanted to come back, but it was impossible: he was at the end of his career and we were investing in young players.’MORE: Martin Keown speaks out on William Saliba ‘mystery’ as Arsenal make U-turn over loan dealMORE: Thomas Partey names five Arsenal legends he idolised – including Patrick Vieira and Thierry HenryFollow Metro Sport across our social channels, on Facebook, Twitter and Instagram.For more stories like this, check our sport page.last_img read more

first_imgThe home at 815 New Cleveland Rd, Gumdale.The main home has a dedicated media room, library and office. Outside is a 25m heated pool and spa with water feature and glass fencing. A shed at the front of the property includes a single garage, and a self-contained granny flat with kitchenette and bathroom. Towards the back of the property is a three-bay shed, which can accommodate up to 12 cars, and a boat shed. The home at 815 New Cleveland Rd, Gumdale.Back inside, the master bedroom has patio access, a walk-in robe and a huge ensuite with double shower, corner spa, dual basins and separate toilet. One of the remaining bedrooms also has a walk-in robe and the rest have built-ins. The family bathroom has a separate shower and bath and the laundry has plenty of storage and bench space. The home at 815 New Cleveland Rd, Gumdale.THIS sprawling executive home on acreage is on the market in Gumdale. The five-bedroom home, at 815 New Cleveland Rd, has open-plan living, a poolside entertainment area, granny flat and parking for up to 15 vehicles. Marketing agent Michelle Rodgers, of McGrath Estate Agents Bayside Manly, said the property was the “embodiment of modern luxury” and offered a relaxed lifestyle in a sought-after suburb. The house is on a private, fenced 0.99ha block with electric gates and tree-lined driveway. center_img The home at 815 New Cleveland Rd, Gumdale.The front doors open to a foyer with fountain and a lounge room with built-in shelving and timber floors. More from newsCrowd expected as mega estate goes under the hammer7 Aug 2020Hard work, resourcefulness and $17k bring old Ipswich home back to life20 Apr 2020The hub of the home is the open-plan living, dining and kitchen area with tiled floors, wet bar and bi-fold doors opening to the poolside patio. The big kitchen has stone benchtops, stainless steel appliances, walk-in pantry and a breakfast bar, while the wet bar has bi-fold windows that open to the patio with a built-in barbecue and sauna.last_img read more

first_imgSIMEC Atlantis Energy has announced plans to retrieve two of the four installed MeyGen tidal turbines following diagnosis of a generator fault by the onboard monitoring systems.The project operators plan to retrieve two of the Andritz Hammerfest Hydro (AHH) turbines during this month for inspection and maintenance by the turbine supplier, SIMEC Atlantis informed.The turbines, both of which are covered under warranty, will be inspected onshore and, subject to confirmation of the fault diagnosis, the repairs are expected to be completed within approximately two months.The remaining AHH turbine and Atlantis’ own AR1500 turbine continue to generate electricity, the company noted.At 6MW rated capacity, MeyGen is the world’s largest tidal stream array and has 392MW of further development capacity under its seabed lease.The project formally completed its construction and commissioning phase in March 2018 and is currently in the warranty period.MeyGen has generated over 8GWh of energy to the grid to date, according to SIMEC Atlantis.The array also exported a world record 1.4GWh of electricity to the grid in a single month this year, which would have satisfied the electrical requirements of 5420 average UK homes during that month.last_img read more

first_imgPaddy McNair has revealed his Manchester United team-mates were cheering on Northern Ireland’s push for Euro 2016. McNair made his first competitive start in Thursday’s 3-1 win over Greece, a result that guaranteed Michael O’Neill’s men would be heading to France. And there were some big names from the Old Trafford dressing room who were glad to see McNair and company succeed. Press Associationcenter_img “Yeah, they wanted us to qualify. Everybody wanted us to qualify,” he said. “Wayne Rooney and Michael Carrick were rooting for us and I’m sure if we get them (England) in the draw there will be a few words exchanged. “We’ll get them in the later stages maybe and knock them out,” he added, with a laugh. “Ander Herrera texted me (after the match) and I put a few pictures on Instagram and a few of them liked it.” McNair was pencilled in to play a holding midfield role against Greece but was shifted to right-back when Aaron Hughes pulled out with a calf injury. He prefers playing centrally, in midfield or defence, but was happy just to have the chance to make his Windsor Park bow in such a high-profile fixture. “It was a crazy night,” he said. “We just wanted to get the job done but I don’t think it has sunk in that we have qualified. It is a brilliant feeling. “It was my very first game at Windsor Park and it was a great game to make my debut there. When Michael said I was starting I was really looking forward to it. “It was our biggest game in 30 years and for it to be my first game at Windsor it was a good one.” last_img read more

first_img Comments Kayla Alfonso walked off the field struggling to catch her breath. The freshman defender had reason to be winded. The Orange was contending with one of the fastest teams it has played against all season, and it was taking a toll on its players. Syracuse went down in a blur against Connecticut right from the beginning. SU head coach Phil Wheddon knew the Huskies were going to come out fast, but his players struggled all game to find a remedy for its opponent’s speed. ‘We prepared our team to play against a fast team, and they were prepared to play against dangerous players up top,’ Wheddon said. ‘I think the pace to the game was a shock. The players that they had running through the midfield, we didn’t match them for pace.’ Goalkeeper Brittany Anghel had to defend against an uncontrollable offense that was able to find space all over the field. Anghel was aware of the Huskies’ plan to attack with numerous players, but it left the defense exposed.AdvertisementThis is placeholder text Anghel made a career-high 10 saves in the losing effort, but was still disappointed with the result. ‘They were sending a lot of players forward, and I think it’s important for us to be aware of seeing the whole field, across the field,’ Anghel said. ‘They had, like, five runners coming at us, and we need to drop our midfield back, and we need to plan accordingly because we knew they were going to come at us.’ The Orange fell behind just two minutes into the game. From that point forward, SU needed to try and score. But that risk ended up enabling UConn to counterattack more effectively. Drawing Syracuse midfielders into the attacking third gave the Huskies the ability to move forward quickly and create odd-man situations. Sophomore midfielder Rosina Callisto noticed how the Huskies were utilizing their speed from the start of the game. The inability of SU midfielders to get back and defend was cause for concern at halftime. ‘We noticed it from the beginning,’ Callisto said. ‘Rachel (Blum) and I were discussing it. Coming out of halftime, we were like, ‘We have to figure out how to adapt to this because they are flying all over the place.” But any plans to shift the momentum in the game would be thrown aside when defender Cecilia Borgstrom picked up her second yellow card of the game. The foul not only put the Orange a man down, but it gave the Huskies more room to operate their speedy offense. Now Anghel had to bail out her defense even more. The field became wide open, and Connecticut’s chances became readily available. ‘At the center of defense, we have to be able to absorb the pressure,’ Wheddon said. ‘At times, we get caught out in the middle of the back and Brittany has to step up for us, and she’s done that on numerous occasions so far.’ The foul caused Wheddon to make appropriate changes to his lineup. The coach placed the sophomore midfielder Blum at center defender. The changes set back any opportunity for the Orange to score, with less midfielders able to move forward. But the Orange defense gave UConn ample opportunities to score without their starting defender. The Huskies continued to take advantage of all of the space in Syracuse’s defensive end. Blum recognized the Huskies turned Syracuse turnovers into scoring chances. ‘They exposed our mistakes really quickly, and they capitalized on that,’ Blum said. ‘I think we need to stay a little bit more compact going down with one player.’ For Wheddon, the lapses in the game were caused by a lack of organization. Connecticut spread the SU defense and was able to make the most of sporadic opportunities. And in the end, it left the entire Orange team winded. ‘I think that we need to iron out some of the issues we’re having at the center of the back, and even that’s not fair to blame the central defenders,’ Wheddon said. ‘The breakdowns are occurring further up the field and allowing players to run through us. I’m not going to point fingers, but we need to organize, and we’ll be working on that in training this week.’ [email protected] Published on September 26, 2010 at 12:00 pmcenter_img Facebook Twitter Google+last_img read more

first_img AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREWalnut’s Malik Khouzam voted Southern California Boys Athlete of the Week PICO RIVERA — Pico Rivera will step back in time Saturday with the return of the historical Huck Finn Parade and Jubilee. The parade will start at 10 a.m. at Jackson Street and will make its way south down Passons Boulevard to El Rancho High School. The parade will feature a variety of floats and marchers representing many community organizations, service clubs and schools. City leaders and community VIPs will also ride in the parade together with Pico Rivera’s oldest resident at 104 years of age. At the high school, parade participants will join the Huck Finn Jubilee at Dons Stadium featuring children’s activities and games, community booths and a Huck Finn look-alike contest. For more information, call (562) 942-9833. Concert raises $10,000 for charity PICO RIVERA — Pico Rivera Cares, a family concert held in October at El Rodeo Restaurant and Nightclub, raised more than $10,000 for Hurricane Katrina relief efforts. The concert is now featured on the city’s cable TV channel, CTV3. People can still help the effort by sending donations to American Red Cross-Hurricane Relief, 6706 Friends Ave., Whittier, CA 90601. Beef taco dinner set by VFW post PICO RIVERA — The Ladies Auxiliary VFW Post 6315 will hold a beef soft-taco dinner fund-raiser from 5:30 to 7:30 p.m. Friday at its facility, 4865 S. Durfee Ave. The dinner includes beans, rice, salad and dessert. Donation is $5.50 per person. For more information, call (562) 949-8159. Credit card fraud topic of program MONTEBELLO — Assemblyman Ron Calderon, D-Montebello, will hold a free forum on the prevention of credit card fraud from noon to 1:30 p.m. Nov. 10 at the Quiet Cannon, 901 N. Via San Clemente, Montebello. Experts from MasterCard, Visa, Discover, American Express and the California Department of Privacy and Protection will provide tips on how owners of brick and mortar stores, e-retailers and other business leaders can detect fraud at the register. Attendees will learn each of the credit company’s process for authorization, how to handle disputes, how to avoid losses from credit card fraud and ways to stop credit card fraud while providing outstanding customer service. Lunch will be provided. For more information or for reservations, call (323) 838-5858. CHP station installs child safety seats SANTA FE SPRINGS — The California Highway Patrol, Santa Fe Springs station, offers free child safety seat-installation inspections each Monday by appointment at the station, 10051 Orr and Day Road. For an inspection appointment, call (562) 868-0503. Tours of Neff Home offered Saturdays LA MIRADA — Free tours of the Neff Historic Site are available from 2 to 4 p.m. the second and fourth Saturdays each month. The site includes the Neff Home, built in 1893 by Andrew McNally of Rand McNally Publishing Co.; Neff barn, which houses displays and artifacts; and the George House, named for the ranch foreman. Neff Historic Site is at 14300 San Cristobal Drive. For information, call La Mirada Community Services at (562) 943-7277. — From staff reports160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set! WHITTIER — Los Angeles County Supervisor Don Knabe will speak at the 11 a.m. Friday lunch of the Whittier Republican Women Federated. The club meets at the Friendly Hills Country Club, 8500 S. Villaverde Drive, Whittier. For reservations, call Pat King, (562) 695-0690. Cost is $17. Huck Finn Parade set in Pico Riveralast_img read more

first_imgPhysiologists have long known that haemoglobin, the molecule that adds the redness to red blood cells and carries oxygen to the tissues, releases its oxygen as the blood vessels constrict.  Now, increasing evidence shows that haemoglobin (composed of four complex proteins that surround a central iron atom) is not just a passive oxygen carrier.  It actually works with other substances, including nitric oxide (NO), to regulate the flow of blood by adjusting the dilation of blood vessels, and NO in response can adjust how efficiently haemoglobin can carry oxygen.  This process, still not fully understood, is presented in a Concepts piece by David J. Singel and Jonathan S. Stamler in the July 15 issue of Nature,1 who speak of the “emergent complexity of haemoglobin.”    Nitric oxide produces dilation of blood vessels.  Apparently it will hitch onto the alpha or beta subunits of haemoglobin depending on the concentrations of oxygen or carbon dioxide present in the blood, acting as a regulator of NO’s activity in dilating the vessels according to need.  For the chemists in the audience,The disposition and reactivity of NO bound to haemoglobin is thus a function of multiple variables, including the other allosteric effectors of haemoglobin (pH; partial pressure of carbon dioxide, pCO2; partial pressure of O2, pO2) and the ratio of their concentrations to haem.  Changes in conditions can give rise to stark, rather than subtle, linear changes in the distribution of NO reaction products.  This complexity emerges both from the cooperative, nonlinear behaviour of the haemoglobin tetramer and from the branched network of coupled kinetic equations underlying this rich chemistry.So when you are walking casually in the woods, oxygen outnumbers NO, which binds to the beta subunits, generating production of NO-downstream products, and your blood vessels relax.  When you see the bear and take off running, the binding of NO changes and “contributes to the matching of blood flow to demand under physiological conditions.”  What happens when the bear has you pinned to the ground and is licking your face?In contrast, when micromolar concentrations of NO arise, as in septic shock, the potential problem of excess S-nitroso-haemoglobin and consequent excessive vasodilation is avoided by sequestering NO on the alpha-haems, which additionally lowers the overall oxygen affinity of the protein.  This chemistry restricts NO bioavailability while enhancing oxygen delivery.NO works with haemoglobin, therefore, in response to physiological conditions to adjust its ability to carry oxygen, without going berserk under stress.  The authors encourage an “appreciation of the complexity” of this process, because “Emerging evidence [shows] that vasodilation by red blood cells is altered in disease, including heart failure, pulmonary hypertension and diabetes….”  Knowledge of this self-regulating activity “should open a new field of investigation and could potentially change the practice of medicine.”    A related paper in PNAS2 explores additional biologic activities of NO and its reaction products in blood plasma, and suggests that “high-affinity, metal-based reactions in plasma with the haptoglobin-hemoglobin complex modulate plasmatic NO reaction products and limit S-nitrosation at low NO flux.”  These products coordinate with hormones, endocrine vasomotor function, and NO transport in the blood vessels.1David J. Stingel and Jonathan S. Stamler, “Blood traffic control,” Nature 430, 297 (15 July 2004); doi:10.1038/430297a.2Wang et al., “Biological activity of nitric oxide in the plasmatic compartment,” Proceedings of the National Academy of Sciences USA, 10.1073/pnas.0402201101, online preprint July 16, 2004.This wonderful story speaks for itself.  We need to be reminded of how many things have to work exactly right for us to do something as simple as taking a walk in the woods.  Things are not getting any easier for those who believe a long series of mistakes produced the human body, to say nothing of bears and forests.(Visited 8 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more