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first_img“Imperial continues to engage in a wide range of exploratory discussions relating to COVID-19 research, with a variety of partners. We have nothing further to report at this stage,” a spokeswoman said, asked about the possibility of challenge trials.Any trials conducted in the United Kingdom have to be approved by the Medicines and Healthcare products Regulatory Agency (MHRA), the healthcare regulator which looks into safety and protocol.The MHRA did not immediately respond to Reuters’ requests for comment, but 1Day Sooner, which lobbies for challenge trials to accelerate vaccine development, welcomed the report.”1Day Sooner congratulates the British government on their plans to conduct challenge trials to test vaccines,” it said in a statement, confirming it would petition the government to house the trial participants.The industry has seen discussions in recent months about potentially having to inject healthy volunteers with the novel coronavirus if drugmakers struggled to find enough patients for final trials.The FT report said that volunteers would first be inoculated with a vaccine and later receive a challenge dose of the coronavirus. It did not name the vaccines that would be assessed in the project.British drugmaker AstraZeneca, and French firm Sanofi both told Reuters that their vaccine candidates were not involved in the program. Britain is planning to host clinical trials where volunteers are deliberately infected with the new coronavirus to test the effectiveness of vaccine candidates, the Financial Times reported on Wednesday, citing people involved in the project.So-called “challenge trials” are expected to begin in January at a quarantine facility in London, the report said, adding that about 2,000 participants had signed up through a US-based advocacy group, 1Day Sooner. Britain said it was working with partners on the potential for human challenge trials without commenting on a specific plan. “We are working with partners to understand how we might collaborate on the potential development of a COVID-19 vaccine through human challenge studies,” a government spokeswoman said.”These discussions are part of our work to research ways of treating, limiting and hopefully preventing the virus so we can end the pandemic sooner.”The FT reported that the studies will be government funded, although 1Day Sooner said it would also launch a petition for public funding of a biocontainment facility big enough to quarantine 100 to 200 participants.Imperial College London, reportedly the academic lead on the trials, did not confirm the studies.center_img Topics :last_img read more

first_imgThe home at 815 New Cleveland Rd, Gumdale.The main home has a dedicated media room, library and office. Outside is a 25m heated pool and spa with water feature and glass fencing. A shed at the front of the property includes a single garage, and a self-contained granny flat with kitchenette and bathroom. Towards the back of the property is a three-bay shed, which can accommodate up to 12 cars, and a boat shed. The home at 815 New Cleveland Rd, Gumdale.Back inside, the master bedroom has patio access, a walk-in robe and a huge ensuite with double shower, corner spa, dual basins and separate toilet. One of the remaining bedrooms also has a walk-in robe and the rest have built-ins. The family bathroom has a separate shower and bath and the laundry has plenty of storage and bench space. The home at 815 New Cleveland Rd, Gumdale.THIS sprawling executive home on acreage is on the market in Gumdale. The five-bedroom home, at 815 New Cleveland Rd, has open-plan living, a poolside entertainment area, granny flat and parking for up to 15 vehicles. Marketing agent Michelle Rodgers, of McGrath Estate Agents Bayside Manly, said the property was the “embodiment of modern luxury” and offered a relaxed lifestyle in a sought-after suburb. The house is on a private, fenced 0.99ha block with electric gates and tree-lined driveway. center_img The home at 815 New Cleveland Rd, Gumdale.The front doors open to a foyer with fountain and a lounge room with built-in shelving and timber floors. More from newsCrowd expected as mega estate goes under the hammer7 Aug 2020Hard work, resourcefulness and $17k bring old Ipswich home back to life20 Apr 2020The hub of the home is the open-plan living, dining and kitchen area with tiled floors, wet bar and bi-fold doors opening to the poolside patio. The big kitchen has stone benchtops, stainless steel appliances, walk-in pantry and a breakfast bar, while the wet bar has bi-fold windows that open to the patio with a built-in barbecue and sauna.last_img read more

first_imgGothenburg-based AP2, one of Sweden’s four main state pension buffer funds, has invested in a social bond that focuses on gender equality, issued by the World Bank.AP2 said the bond met the criteria of the UN’s 17 Sustainable Development Goals (SDGs). The fourth SDG specifically relates to gender equality.The purpose of the bond was to raise awareness of gender issues in general, and to promote the empowerment of women and girls – thereby promoting economic growth, reducing poverty and creating the conditions for a more sustainable society, the SEK336bn (€34bn) pension fund said.A spokeswoman for AP2 declined to say how much the fund has invested in the Canadian dollar-denominated issue. Overall, the bond issue raised more than CAD1.2bn (€787m), according to the World Bank. It said more than 40 investors had placed orders and described the issue as “comfortably oversubscribed”.AP2 said its policy was to reveal the size of investments only twice a year, when it publishes its holdings.Data from the World Bank showed the bond, which carries a coupon of 2.25%, sold just below face value at 99.433% of its target.Some 55% of the investors were based in Canada and 24% were from Europe and the Middle East, the bank said. Asset managers, insurance companies and pension funds made up 42% of the investors by type.Kristalina Georgieva, World Bank CEO, said: “We need US$7trn (€5.7trn) to achieve the Sustainable Development Goals – and we will not achieve them if we leave half our population behind.”This was why the World Bank and Canada were committed to advancing gender equality and the empowerment of women, she said.Last June, AP2 invested an undisclosed amount in a social bond issued by the Netherlands’ NWB Bank to finance affordable housing in the country.last_img read more

first_imgPatience paid off for Lance Arneson in the form of the Saturday night IMCA Modified feature win at Shawano Speedway. (Photo by A and H Photos)By Scott OwenSHAWANO, Wis. (May 6) – Lance Arneson proved what mom always said, that patience is a vir­tue, Saturday at Shawano Speedway.Like a lion stalking his prey, Arneson waited for the optimal moment to pounce, with a turn four pass for the lead on the final lap to win his first IMCA Modified feature of the year.Konnor Wilinski grabbed the lead on lap one as his dad Jerry moved to second. Arneson soon got past Jerry Wilinski to move to second.Konnor Wilinski and Arneson ran away and hid from the rest of the pack as they eventually had a near straight away advantage over third-running Jerry Wilinski. As Konnor Wilinski contin­ued to lead, Arneson stayed within a car length while sizing up the leader and patiently waiting to make a move.Lap after lap ticked away with Konnor Wilinski still leading.  With two laps remaining, Arneson took a peak to the inside. Wilinski shut the door, though, and continued to lead. Entering turn one on the final lap, Arneson again had a nose to the inside of Wilinski but again the leader was faster out of turn two.Entering turn three, Arneson again got inside of Wilinski, and this time he would not be denied as the duo ran side-by-side through turns three and four.  On the front stretch Arneson pulled ahead and beat Wilinski to the checkered flag.Travis Van Straten won a second straight IMCA Sunoco Stock Car feature while Jordan Bahrkoltz hoisted the Karl Chevrolet Northern SportMod trophy.last_img read more

first_imgHans Holbein bids to give Aidan O’Brien a third successive triumph in the MBNA Chester Vase and his sixth in all when facing five rivals on the Roodee on Thursday. Press Association The son of Montjeu, who also held an entry in Friday’s Dee Stakes, is Ballydoyle’s only representative from seven possibles. Hans Holbein, has had a busy spring campaign already winning the latest of two starts last month at Leopardstown. center_img He will be taken on by Godolphin’s Future Empire, who was well beaten by Christophermarlowe in Epsom’s Derby Trial two weeks ago. David Brown saddles Medrano, placed in both his starts in France this term, while Mike de Kock’s Tannaaf, easy Leicester maiden winner Storm The Stars and the Richard Hannon-trained Proposed complete the six-strong field. Four of the six – Hans Holbein, First Empire, Storm The Stars and Proposed – hold entries in the Investec Derby. last_img read more

first_imgToday marks 19 years since the September 11th terrorist attacks on New York City and the Pentagon. Commemorations began at sunrise with the traditional unfurling of the American flag on the side of the Pentagon. In New York City, the traditional reading of the names of the victims will be recorded this year due to the pandemic. And in Shanksville, Pennsylvania both President Trump and former Vice President Joe Biden will pay their respects.Mike Pence and his lovely wife Karen will be in New York. The Vice President is expected to deliver a spiritual message.last_img read more

first_img(REUTERS) – Diego Maradona criticised the faltering Argentina team yesterday and appealed for another chance at managing the national side.A day after they lost 4-2 to Nigeria in a friendly in Russia, Maradona, who last managed Argentina at the 2010 World Cup, hit out the current setup in a short Instagram message.“I am angry because they have thrown away our prestige, but it’s not the fault of the lads,” he said. “I WANT TO COME BACK!!!”Maradona, who is currently coach of United Arab Emirates side Al Fujairah, posted statistics of 11 recent Argentina managers that showed his success rate was 75 per cent, greater even than that of Cesar Luis Menotti, who won the World Cup in 1978, and Carlos Bilardo, who lifted the trophy in 1986 when Maradona was at his brilliant playing best.“Who won most?” Maradona wrote. “We draw our own conclusions.”The former Boca Juniors and Napoli striker led Argentina to the quarter-finals in Germany, where they were knocked out by the host nation.Current Argentina coach Jorge Sampaoli has had an inconsistent start to his tenure since taking charge in June, winning four of his first eight games, but only one of four competitive fixtures.The Argentines only qualified for next year’s World Cup finals thanks to a hat-trick from Lionel Messi in their last game against Ecuador.last_img read more

first_imgAfter a disappointing loss to Oregon, the USC women’s basketball team looks to bounce back this week against two of the top teams in the Pac-10.USC (13-7, 7-2) kicked off the second half of its conference schedule with road games against California and No. 2 Stanford. The Women of Troy beat Cal (11-9, 5-4) earlier this season on a last-second 3-pointer by sophomore guard Ashley Corral.“We had a tough game against Cal here at home and they’re probably coming out to avenge that loss,” senior guard Hailey Dunham said. “We have to go in with a new focus and correct the things we didn’t do as well the first time we played them.”One thing USC needs to figure out is a way to slow down the Golden Bears’ inside-out combination of freshman forward/center DeNesha Stallworth and redshirt senior guard Alexis Gray-Lawson. In the first game between the two teams this season, the duo combined for 50 points.“After that we switched up our post defense,” USC assistant coach Mary Wooley said. “We’re really challenging our [bigs] to play better defense because they let a freshman get 30 points on them.”USC must also be ready for Cal’s pressure defense. The Women of Troy turned the ball over 18 times against Oregon and spent practice discussing how to overcome it.“A lot of it comes down to recognizing where we need to be on the basketball floor,” Wooley said. “We try and tell them one thing that counteracts pressure is calmness. If you stop and slow down, the pressure can’t be as effective.”The road does not get any easier for the Women of Troy after that. USC battles No.2 Stanford (19-1, 9-0) on Sunday in a game that will be televised locally. Stanford won handily at the Galen Center last month and has yet to be challenged this season in the Pac-10.“Every game that we play we want to measure ourselves against Stanford,” Wooley said. “If we can come out and compete with them I think we can surprise some people.”This weekend could feature the debut of redshirt junior guard Jacki Gemelos. The former McDonald’s All-American has been cleared for action after sitting out the last three seasons with knee injuries.Other members of the team are dealing with injury concerns as well. Corral, who leads the team in scoring, sat out of practice on Monday with a sore heel.“Everybody’s got bumps and bruises, but I don’t think we’re beat down at all,” Dunham said. “We’re coming out fired up about the Oregon loss.”The Women of Troy play Cal at 7 p.m. tonight. They take on the Cardinal at 1 p.m. Sunday.last_img read more

first_imgThe Battle of California begins this week for the USC women’s volleyball team, who will put their 12-1 record on the line against their Northern California rivals.Veteran presence · Senior middle blocker Alexis Olgard’s hitting percentage (.418) for USC this season is her best career mark. – Ralf Cheung | Daily TrojanAfter a successful sweep of Utah in Salt Lake City, the No. 2 Women of Troy return this week to the Galen Center, where they will host No. 7 Stanford on Friday night and California on Sunday night.USC (12-1, 2-0) remains undefeated in conference play with a 3-0 sweep of Utah last Sunday. Sophomore outside hitter Samantha Bricio paved the way with 16 kills and four service aces, and senior libero Natalie Hagglund once again anchored a strong defensive effort with 18 digs.Since falling to University of San Diego on Sept. 13, USC has rattled off six straight wins and has yet to be pushed to a fifth set by any opponent. But the squad is aware that a long, tiring match could very well be looming against the Cardinal.“Stanford is really playing well. As you can see, last night they beat up on UCLA,” head coach Mick Haley said. “Offensively, they’re scoring at a very high clip, so we’ve been trying to get comfortable with some of the things they do and see if we can design some things that will cause them some difficulty.”The Cardinal (10-2, 3-0) will arrive at USC on the heels of an impressive sweep over No. 16 UCLA, turning back the Bruins 25-17, 25-15, 25-16 to stay unbeaten in conference play. Stanford has won eight straight games to improve to 10-3 and features three returning All-Americans in senior middle blocker Carly Wopat, sophomore middle blocker Inky Ajanaku and senior outside hitter Rachel Williams.On the other side, the Women of Troy have the offensive firepower and youth to match the Cardinal. Freshman outside hitter Ebony Nwanebu earned Pac-12 Freshman of the Week honors for the second time this season after posting 17 kills to beat UCLA and nine to defeat Utah. Sophomore Samantha Bricio, who earned the honor herself five times last season, is second on the team with 3.2 kills per set and leads the entire conference with 32 service aces.It was USC’s upperclassmen, however, who knocked off Stanford last November, and Haley will be counting on his top guns to perform.“I always expect our older players to perform well when you have competition like this,” Haley said. “This is the fourth year that our seniors have met Stanford, and all three of them have played all four years. It’s a constant battle to see who comes out on top. We’ve played these guys quite even and it’s been a sensational series, so I expect that to continue.”Though he didn’t note any specific area of improvement ahead of Friday night’s tilt, Haley once again emphasized the need to keep improving against stiffer conference competition and praised his squad’s preparation.“I know Stanford’s going to be really good, so we have some things that we’re trying to add that will be helpful,” Haley said. “Basically we’re just trying to get better at what we do. We’ve been working very hard with that.Cal (8-3, 1-1) started off its season with six straight victories, but the Golden Bears have lost three of its last four games to fall out of the national rankings.When the Bears do triumph, they do so in dominant fashion — all eight of their wins have been sweeps. Outside hitter Adrienne Gehan averages 4.35 kills per set to lead Cal in scoring.But Haley is confident USC’s diligent preparation will yield positive results against their rivals from the Bay.“I’m very pleased with the players’ attitudes and efforts so far,” Haley said. “They’ve been very good in their preparation, and I feel that we’re on the right page.” Follow us on Twitter @dailytrojanlast_img read more