first_imgAdvertisement Advertisement Metro Sport ReporterSaturday 9 Nov 2019 1:54 amShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link1.7kShares Unai Emery believes mitigating factors have hampered Arsenal this season (Getty Images)Unai Emery believes multiple issues away from the pitch have been responsible for Arsenal’s poor performances this season.The Spaniard is under huge pressure having guided the Gunners to just one win in their last five Premier League games.Arsenal are already six points behind fourth-placed Chelsea and fans are calling on the club to sack Emery just 18 months after he replaced Arsene Wenger as manager.Emery, however, feels incidents at the club including the attempted robbery involving Mesut Ozil and Sead Kolasinac, Laurent Koscielny’s decision to go on strike in order to force through a transfer before the season had begun, and Granit Xhaka’s clash with supporters have had an impact on the team.ADVERTISEMENT Laurent Koscielny went on strike to leave Arsenal this summer (Getty Images)‘I’m not really disappointed with our work,’ said Emery.AdvertisementAdvertisement‘I am being realistic because some circumstances did not help us to achieve our best performance.‘The circumstances with Ozil, Kolasinac, Koscielny and, remember also, that if he [Koscielny] was here as captain, that would give us no problem.‘Then Xhaka’s circumstances.’More: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityEmery also conceded that his Arsenal players had failed to follow his game plan.‘We are not playing really with a good performance to impose our idea, impose our capacity on each match,’ said the Arsenal manager.‘I said to them we rarely lost at home but we didn’t impose as I want and will want in the next matches in our process.‘It’s a process we need to do with the players.’More: Arsenal FCArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira movesThomas Partey debut? Ian Wright picks his Arsenal starting XI vs Manchester CityArsene Wenger explains why Mikel Arteta is ‘lucky’ to be managing Arsenal Comment Unai Emery explains reasons why Arsenal have struggled this seasonlast_img read more

first_img Markets and investors recoiled Saturday over news that ratings agency “”Standard & Poor’s””:http://www.standardandpoors.com/home/en/us slapped U.S. Treasury debt with a downgrade, shifting credit ratings for the world’s largest economy from the long-prized AAA rating to a weaker AA+ rating. In response, Treasury yields dipped over Monday, as housing analysts suggested that the hyped downgrade would hurt borrower confidence more than mortgage rates.[IMAGE]Rather than run from U.S. Treasuries, investors created a buying spree Monday, sending 10-year Treasury yields down to 2.43 percent from 2.56 percent Friday, according to “”CNNMoney””:http://money.cnn.com/2011/08/08/markets/bondcenter/treasuries_downgrade/. With respected mortgage companies “”Bankrate””:http://www.bankrate.com/ and “”Freddie Mac””:http://www.freddiemac.com/ ├â┬ó├óÔÇÜ┬¼├óÔé¼┼ô which suffered a downgrade Monday alongside fellow GSE “”Fannie Mae””:http://www.fanniemae.com/kb/index?page=home ├â┬ó├óÔÇÜ┬¼├óÔé¼┼ô yet to release mortgage rate updates, “”MonitorBankRates.com””:http://www.monitorbankrates.com/mortgages/mortgage-rates-decline-on-u-s-credit-rating-downgrade-30-year-mortgage-rates-at-4-28 signaled a plunge in mortgage rates over recession fears, citing falls in 30-year fixed-rate loans to 4.28 percent and 15-year mortgages to 3.50 percent, down from 4.48 percent and 3.69 percent, respectively, from last week.Housing analysts and economists reacted to the news with a mix of alarm and unconcern.A “”story””:http://online.wsj.com/article/SB10001424053111904140604576494572068990408.html in the “”_Wall Street Journal_””:http://online.wsj.com/home-page quoted Karen Shaw Petrou, managing partn:er at research firm “”Federal Financial Analysis””:http://www.fedfin.com/, as saying that a downgrade could “”do nothing but harm”” the U.S. mortgage market. She asks: “”The question is how much?””””My thoughts are that [mortgage] rates may be impacted by 30 basis points at maximum,”” Lawrence Yun, SVP and chief economist with the “”National Association of Realtors””:http://www.realtor.org/, wrote in an “”article””:http://economistsoutlook.blogs.realtor.org/2011/08/08/u-s-credit-downgrade/. “”Mortgage rates will most likely move in the same direction as the government borrowing rate, because there is government backing of mortgages on nearly all mortgage originations in today’s market.””[COLUMN_BREAK]””Even if rates were to rise because of the downgrade, this fact is less important in light of the current overly-stringent underwriting standards and the general lack of consumer confidence about the economy,”” Yun added. “”A 30-year fixed rate rising from 4.3% to 4.6% will not change the housing game that much, but a return to normal underwriting standards and a boost to consumer confidence will be the true game changer.””Celia Chen, senior research director and housing specialist with “”Moody’s Analytics””:http://www.moodys.com/Pages/atc003.aspx ├â┬ó├óÔÇÜ┬¼├óÔé¼┼ô the ratings agency that preserved U.S. debt credit ratings along with fellow agency “”Fitch Ratings””:http://www.fitchratings.com/index_fitchratings.cfm ├â┬ó├óÔÇÜ┬¼├óÔé¼┼ô joins Yun in downplaying the role a downgrade will ultimately play in still-reeling mortgage markets.She calls the ratings shock a “”psychological blow on the nation”” that will largely bypass the housing sector and economy at large, chalking up wherewithal in global equity and bond markets to investors who stayed on the alert about a S&P downgrade for U.S. debt ratings.””Investors are still buying 10-year Treasury bonds [at] record-low rates, indicating that they are not worried about the U.S. defaulting,”” she says. “”Thus mortgage rates will not be much affected by the downgrade. They will remain low [and] thus a positive for the housing market.””She predicts that an unaffected job growth outlook will “”fuel strong demand for [the] housing”” sector.Chen adds: “”The downgrading does, however, heighten the risk that the nation ends up back in recession, as the selloff ends up feeding on itself. If the nation double-dips, housing’s fledgling recovery will be squashed.””Explaining its reasons for the debt downgrade, S&P issued a “”report””:http://www.standardandpoors.com/servlet/BlobServer?blobheadername3=MDT-Type&blobcol=urldata&blobtable=MungoBlobs&blobheadervalue2=inline%3B+filename%3DUS_Downgraded_AA%2B.pdf&blobheadername2=Content-Disposition&blobheadervalue1=application%2Fpdf&blobkey=id&blobheadername1=content-type&blobwhere=1243942957443&blobheadervalue3=UTF-8 that signaled low confidence in U.S. public policymakers and federal institutions.””The downgrade reflects our opinion that the fiscal consolidation plan that Congress and the Administration recently agreed to falls short of what, in our view, would be necessary to stabilize the government’s medium-term debt dynamics,”” S&P said. “”More broadly, the downgrade reflects our view that the effectiveness, stability, and predictability of American policymaking and political institutions have weakened at a time of ongoing fiscal and economic challenges.”” Treasuries, Analysts Respond to U.S. Debt Downgrade August 8, 2011 450 Views in Data, Government, Origination, Secondary Market, Servicingcenter_img Agents & Brokers Bankrate Fannie Mae Fixed-Rate Mortgage Freddie Mac Investors Lenders & Servicers Mortgage Rates National Association of Realtors Processing S & P Index Service Providers 2011-08-08 Ryan Schuette Sharelast_img read more

first_imgDermatologist examining patient in clinic, closeup. Image Credit: Africa Studio / Shutterstock By Dr. Ananya Mandal, MDJul 18 2018West Australian researchers from Edith Cowan University have managed to develop a blood test that is capable of diagnosing melanomas before they can spread to other parts of the body. The study titled, “A diagnostic autoantibody signature for primary cutaneous melanoma,” was published in the latest issue of the journal Oncotarget. Source:http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=25669&path[]=80326center_img The team of researchers have devised the blood tests that can detect autoantibodies that the body usually makes when it encounters skin cancer cells. They conducted a trial involving 105 people with melanoma and successfully detected the cancer in early stages in 81.5 percent of the cases using the blood test. Nearly 14,000 such skin cancer cases are detected each year in Australia with at least 2000 dying from it annually making it the fourth common type of cancer in Australia. Melanoma forms around 1 to 2 percent of all skin cancers but is considered to be the deadliest.The study was led by Pauline Zaenker, part of the Melanoma Research Group at the Edith Cowan. According to her common practice now to detect skin cancer is by analysing skin biopsies. However three fourths of all biopsy samples come back negative even in presence of the cancer, she explained. With advent of this test, the doctors would not need to depend on these costly biopsies alone which are invasive as not always reliable she said. Biopsies for detection of skin cancers costs Australia $201 million a year she added. Of this $73 million is spent on tests that come back false negative.Related StoriesDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustFinger-prick blood test could help prevent unnecessary antibiotic prescribing for patients with COPDPhysicians trained in dermatoscopy can improve odds for early detection of melanomaAccording to Zaenker, as soon as the melanoma develops, the body begins to produce these antibodies and this helps in the detection of the cancer in early stages using this blood test. She added that there are no other biomarkers that can detect the cancer this early in the cancer. She said that the team examined 1627 different types of antibodies before they found that there was a combination of 10 antibodies that could predict that a person had the melanoma when compared to healthy persons. Survival after detection of skin cancer in early stages is 90 to 99 percent which drops to half if it is detected once the cancer has spread to other organs she explained.According to the head of the Melanoma research group, Professor Mel Ziman, this study is to be followed up with a clinical trial, which if successful could mean that this test would be clinically used in around the next three years. She said that this would provide a “diagnostic certainty” before biopsy results when screening people for melanoma. This could especially be useful in those with a higher risk of melanoma. High risk individuals, she explained, are those who have pale skin, large number of moles and a family history of skin cancer.According to the Cancer Council, the best protection against melanomas is protection against the sun’s harmful ultraviolet rays. Melanomas usually show up as skin lesions that have an irregular surface and edges and may vary in colour from black, brown, blue, red, white, grey etc. If not treated, this cancer is capable of spreading deeper into the skin from where it is carried to other organs via lymphatic channels and blood vessels. Cancer Council Australia chief executive Professor Sanchia Aranda called this new study an “interesting development” and hopes that it would be proven in larger clinical trials in the near future.last_img read more